 Abstract ferritin has been widely used in drug delivery in recent years due to its unix spherical nano-cage structure. In addition, the natural targeting and good biocompatibility of ferritin make it an excellent drug delivery system. Therefore, ferritin has shown a broad application prospect in the field of nanomedicine. In this perspective, we will describe ferritin-based drug delivery system, ferritin-based drug delivery system for tumour treatment, and future challenges in ferritin development. Hopefully, this perspective may inspire the future development of ferritin-based drug delivery systems for tumour treatment. This article was authored by Xi'an 2, Peter Tomashev, Yong Chen, and others.