 The researchers have discovered that the reticular activating system, IAS, which is located in the brain stem, plays a key role in episodic memory formation. The IAS is responsible for regulating sleep and wakefulness, as well as alerting the brain to external stimuli. It also helps to maintain attention and focus on tasks. When the IAS is activated, it can lead to increased synchronization between the prefrontal cortex and the hippocampus, which is important for forming memories. This article was authored by Manasa Jayachandran, Tatyana D. Vienna, Andy Garcia, and others.