 This study investigated the role of extracellular vesicles, EVs, in the spread of hepatocellular carcinoma, HCC, to the bones. The researchers found that EVs released from HCC cells in bone metastases were able to transfer microRNA, 3190, MIR, 3190, which was then used to increase the metastatic potential of HCC cells. This increased metastatic potential was due to decreasing the levels of ALKBH5, a protein that normally prevents cancer cell growth. In addition, the researchers developed a novel therapy using antagoners loaded with MIR, 3190 to block the spread of HCC cells to the bones. This study provides important insight into how EVs can be used to spread cancer to other parts of the body, and suggests a new approach to treating HCC in patients with bone metastases. This article was authored by Shin Chi Han, Lin Shue, Yi Wei, and others.