 In this study, the authors assess changing symptom profiles associated with different SARS-CoV-2 variants from May 2020 to March 2022 in England. Using data from the React1 study, they find that Armacran infection is more often associated with cold and influenza-like symptoms, and less with loss of taste and smell. This article was authored by Matthew Whittaker, Joshua Elliott, Barbara Bodnia, and others.