 This systematic review evaluated the effectiveness of various public health interventions to reduce the spread of COVID-19. The results suggest that travel restrictions, border measures, quarantining of travelers arriving from affected countries, city lockdown, restrictions on mass gatherings, isolation and quarantine of confirmed cases and close contacts, social distancing measures, mandatory mask wearing, contact tracing and testing, school closures and personal protective equipment use among health care workers were all effective in reducing the spread of the virus. This article was authored by Aymen Ayuni, Jahan Matug, Wa Fodduib and others.