 Staphylococcus aureus bacteremia, SAB, is a serious infection often associated with high mortality. Recent studies showed that mortality rates have decreased over time, but still remain high at around 25 percent. Factors associated with mortality include female gender, older age, higher macabre score, previous antibiotic use, presence of a central venous catheter, neutropenia, severe sepsis, septic shock, and methicillin-resistant Staphylococcus aureus MRSA. Monomicrobial bacteremia is negatively associated with mortality. In addition, inappropriate empirical antibiotic treatment and non-adherence to guidelines were observed. This suggests that further efforts are needed to improve diagnosis and treatment of SAB, including optimization of diagnostics, increased involvement of infectious diseases specialists, educational sessions, and the creation and implementation of local guidelines. This article was authored by Petros Ioannou, Maria Zachariadaki, Despoina Spensuri, and others. We are article.tv, links in the description below.