 The study evaluated the antioxidant capacity of pomegranate, punica granatum, juice extracts from peel and seed. The results showed that the ethanol extract of pomegranate peel had the highest antioxidant activity, followed by the water extract. The ethanol extract exhibited the strongest antioxidant activity against both ABTS plus and DPPH radicals, while the water extract displayed the greatest antioxidant activity against TPTZ radicals. Additionally, the ethanol extract of pomegranate peel had the lowest IC50 value for inhibiting alfidlicosidase, alflamylase, acetylcholinesterase, and human carbonic anhydrase 2, HCA2, enzyme activities. Furthermore, the ethanol extract of pomegranate peel had the highest antimicrobial activity against Escherichia coli and Staphylococcus aureus bacteria. Overall, these findings suggest that pomegranate peel extract may have potential applications in food preservation and healthcare. This article was authored by Hassan Karajesali, Abubakar Aizal, Ikram Kurechi, and others.