 Multipurpose prevention technologies, MPTs, represent an innovative approach to addressing multiple health issues simultaneously, such as HIV, other sexually transmitted infections, STIs, and unintended pregnancies. To date, most MPTs have been developed primarily for HIV prevention, but many also contain compounds that are effective against non-HIV STIs. In order to ensure that these products reach those who need them most, it is important to identify key research gaps and priorities, and develop a strategic, collaborative, and well-funded response to address them. This article was authored by Bethany Young-Holt, Ariane van der Stratten, Taryn Barker, and others.