 Exosomes are small membrane vesicles released by most living cells, which contain proteins, nucleic acids, lipids, and other molecules specific to their originating cell. These vesicles are capable of transferring cell-specific constituents between cells, making them important for prognostic, diagnostic, and therapeutic purposes. However, current methods for exosome isolation are complex, time-consuming, require large sample volumes, and produce low-purities limiting their use in research and clinical applications. Recently, microfluidic chip technology has been developed as a promising alternative for efficient, simple, and affordable exosome isolation. This technology offers several advantages such as high throughput, low cost, and easy scalability, making it suitable for large-scale production of engineered exosomes for cancer diagnosis and treatment. This article was authored by Jiaxi Chen, Pei Long Li, Tai Zhang, and others. We are article.tv, links in the description below.