 The advance in nanotechnology has opened up new therapeutic horizons for silver, and interactions between viral biomolecules and silver nanoparticles suggest that nanosystems may enhance current prevention of infection and antiviral therapies. Silver nanoparticles have been studied particularly on HIV, where the mechanism of antiviral action of the nanoparticles as well as the inhibition of transmission of HIV-1 infection in human cervix organ culture has been demonstrated. This review discusses recent advances in the understanding of the biocidal mechanisms of action of silver nanoparticles. This article was offered by extrapantarant Liliana, Garza Trevino, Elsa N, Laura Lombato, H, and others.