 This paper proposes a novel model of the neurovascular coupling which explains several important features of the coupling including the linear and non-linear regimes, the negative vascular response, undershoot, and the emergence of a calcium-driven hemodynamic response function. The model also shows how information is encoded and transmitted from the neuron to the vasculature, and how frequency modulation of astrocytic calcium dynamics plays a key role in this process. Additionally, the model links neuronal activity to the bold signal, allowing for the detection of neurodegenerative diseases based on changes in the neurovascular coupling. This article was authored by Federico Tesla, Margelina Lin, and Alain Distecx.