 Okay, imagine a rainy day and think about how you're feeling about that. Maybe it reminds you as a cold and gray and sad day, right? But as all we know, that rain has a lot of benefit for us. It can replenish rivers, it can grow plants and so on. So it actually depends on our perspective that how we feel that something is optimistic or pessimistic. And you know, that's what we call it the cognitive bias. And you know, it's completely fine to feel sad time to time because, in fact, we have some natural reverse system in our brain that helps us to cope with stress and negative feeling. And one of these reverse systems is called opera system. And if it's impaired, it causes some negative feeling and depression. So let me just tell you some facts about depression. In Europe, for example, three out of four patients with depression do not respond adequately to their medication. And also it takes time, usually six weeks or more, to start to show the benefit of medication. So it's kind of the urgent need to find a fast-acting treatment. And one approach can be to find a measurement of treatment response using optimism. My project has developed an annual model to show optimism or pessimism of tested draw in animal. So in this model, we face the animal with two balls with different materials, including a chocolate as a reward inside. And one of these balls is only available when the animal is injected with tested draw. And the following day, the animals should just choose one of these balls during the several trials. And if the animal choose the balls that pair with the drug more than the other one, it means that the drug causes optimism. Here in the graph, you can see when we inject this red hormone, if you follow the red line, the animal show kind of the pessimistic view. On the other hand, when we inject the drug, in this case, the opry base drug, if you follow the green line, you can see that it's blocked the negative feeling and actually stimulates the reward system and show kind of optimistic view. So using this approach, we can establish that which treatment that patient will respond quicker. And you know that the drug that I use in this model that shows the positive effect is currently in development using patient echelonics. And that's really makes me optimistic about the future of treatment for depression. So in the end, I would like to say thank you very much for your optimistic attention. So we should just be optimistic to fight against depression. Thank you.