 Good morning, everyone. My name is Janan. I am a faculty at the Media Lab, and our group is located at the fourth floor of this building. And first, I will tell you a little bit about our group name. It's called conformable decoders. As a group, we believe that we live in an ocean of physical patterns, hard beats, respiration, neuronal activity, temperature change, and so on. And all these physical patterns contain information in coded ways. And as a group, we would like to decode these physical patterns and try to understand how our body is talking to us. And decoders are mainly our devices. These devices can have intimate integration with any curvy body parts of yourself, and translate these biological patterns into electrical language so that we can create a smart interface between patients and medical doctors. Overall, in our group, we do not only specifically target one single organ, whereas we have a bold dream and we would like to target many organs via our wearable, implantable, and attachable devices, and try to understand how these body parts are talking to us. Imagine you have an implantable device in your deep brain, which reads your neuronal potential. But at the same time, imagine that you have an adjustable pill, electronic pill, in your stomach, which can tell the pH and mortality change at the same time. So these two organs can systematically, in a system level, can talk to each other and we can make better treatment methodologies which are not currently available in daily life. In the coming slides, I will, and of course, we do all these mechanically adaptive, flexible, stretchable electronic devices in a special lab which is called Yellow Box. Because yellow is not only my favorite color, it's also we need this yellow color because we use UV-sensitive polymers, and we need to block all the UV lights which make our clean room look like a yellow color like this. And the feature size of our devices are so tiny, that's why we don't want any dust particle to be a part of the device, otherwise the devices will not be functional. So we cannot just do our experiment in regular labs and regular rooms. We use very special environment to help up heather filters that we have on the top of the ceiling of our clean room, so that we can end limited dust particles in the lab to do our special experiments. And this is how we look like, like minions in the clean room. You can now recognize who is who. And this is, maybe we can lower down the volume a little bit. This is how we do our experiments. We first wear special clothes like bunny suits so that we can block all the particles coming from our clothings. And we go inside the clean room as a cohort. We work as a body system because we use really very sensitive polymers and strong acids, so we don't want any safety problem to occur in our lab. And we mainly use traditional micro fabrication tools, but we hack them for our evolving research needs. We use traditional mask aligners, but we use them for pick and place tools, especially for brittle ceramic materials. And we make these devices in stretchable and flexible formats so that they can have very intimate connection with any curvy parts of yourself and gather all the information in an effective way and create big data. And while using this data, we use machine learning to come up with new ways for body language to tell us. Today's electronics are stiffer up to six orders of magnitude compared to soft tissue that we have in our body. So when you want to integrate this part electronics, planar heart electronics, with your soft body, there are severe challenges in mechanics mismatch and geometrical form mismatch. Since we cannot change the biology yet, we change the electronic devices. Given that we have limited time, I'll just highlight three of our projects and tell their main purposes. The first project is about heart. We created a malleable device which can be laminated on your internal organs such as heart beats, heart lungs and diaphragm to generate electricity through the piezoelectricity. We are core materials for our devices based on the piezoelectric materials. So whenever they are deformed, they can produce voltage and current. And we can use this electrical power to power our biomedical devices. For instance, for pacemaker, we have to change this every six to seven years due to the depleted battery. But with our technology, we can harness the mechanical energy from our internal organs and feed the electronics accordingly. Right now, we also work on a variable fashion of the same device platform at the media lab where we use these devices on your joints such as knee or we embed them in our textiles such as your trousers or underwear. Whenever you walk, during your daily activities, you create the electronic power. You also use this to track your gait so that you can understand your neuronal activity with implantable device but at the same time, you can check your gait mortality and it can tell the state of your Parkinson's disease. We work with clinical doctors and we try our devices on Parkinson's patients. The other device is an ingestible pill that you can just kind of a fantastic watch. The device can travel all the way from your mouth well to the other end without involving any scoving or prodding involved. You can take this device because our devices are flexible, so you can roll them in place in a dissolvable capsule. Via endoscopy, you can lower it down from mouth to the GI and the dissolvable capsule dissolves away and the device opens up and stick on a stomach lining. Given that we have piezoelectric component on our device, whenever you eat, whenever you drink, this device will give you a voltage output as a function of the food that you intake. So this is simply a fit bit for your stomach. This is also a nice way to understand how the mortality is functioning and happening with the implantable device that you have in your dip brain. So I'll skip this because we don't have enough time. And the next device is an implantable device. This time it's not wearable, it's perfectly implantable. And we go inside the dip brain. It's called MINE's Minimally Invasive Neuronal Drug Delivery System, which is a needle type structure which can go inside the dip brain and can be remotely controllable with micro pumps to infuse multiple drugs on demand. Why we do that? If you have Parkinson's disease, you need to take the drugs orally or intervenously, which is unnecessarily affecting your whole body. But with this device, we infuse picoliter of drugs on demand. But at the same time, we read out the neuronal potential to create a closed-loop system. So we infuse whenever we need it. We also, given that we are inside the dip brain, we can change the behavior of the animals within seconds by just sending in smart codes through our computer. So we can let the animal turn right or left, run and stop by simple codes that we send from our computers. So this is a tiny video that we created. And again, we work with medical doctors at MGH, as well as at Koch Institute and McGovern Brain Institute, including my students at the Media Lab. This is a device which has very tiny components. These components are thinner than your hair fiber, so you cannot hold them by hands. That's why we use microscope and mask aligners in clean room to assemble them all together in a very tiny stainless steel tube with a diameter of 150 micrometer. And this needle can allow us to go inside the brain with no minimal deflection so that we can target a specific location inside the brain to infuse multiple drugs on demand. And we use two different micro pumps for two different drugs. And with the help of these remotely controllable micro pumps, even though your doctor is away, it can send a code from your computer and then infuse the drugs on demand. And given that we do micro fabrication, we make these devices larger for large animal models such as mech-hux or eventually for human beings and smaller for rat models. And because we have a tiny structure in our internal infusion cannula, we can create a very organized and well-defined bolus areas inside the deep brain. For this specific application, we target a special location inside the brain which is called substantia nigra, and we infuse muscumal to have the device to create a hemiparkinsonian stage. With the muscumal infusion, as seen here, sorry, it's a little bit graphic, you can make the animal to turn and right and left, and you can change this turning points, number of turns, or the interval between the turns by just infusing different types of drugs or different infusion periodicity through your device. Not only little animals, we also use these devices for large animals such as mech-hux. And by infusing different drugs, we can fire the neuronal activity or we can silence it with ACSF or muscumal. And the first time ever in the literature, we demonstrated that we can infuse two different distinctive drugs inside a large animal model mech-hux and create sub-millimeter cubic volumes to infuse picolotters of drugs which are six orders of magnitude smaller that you take orally or intervenously, so you decrease the systemic toxicity really so well. And with this, I would like to thank all of you for listening and also my students and collaborators. Thank you.