 Experts know that processed red meats are likely to raise the risk of cardiovascular disease and death but are unprocessed meats, fish, and poultry less harmful. New research investigates. Everill studies have established a link between consuming processed meat such as bacon, hot dogs, sausages, and other similar meats and an increased risk of cardiovascular disease, CVD, and death. The higher amount of saturated fats in these foods, along with a higher level of salt and preservatives, might explain these associations. Newer research has suggested that even a low amount of these foods is enough to jeopardize health. But what about other meats, such as unprocessed red meat, poultry, or fish? Do these foods affect cardiovascular risk and longevity in the same way? Here, the research is more mixed. The results of several studies vary partly because the methods were different and partly because the existing prospective cohort studies had their limitations. So, to fill this gap in the research, a group of scientists led by Victor W. Jong, Ph.D., of Cornell University in Ithaca, New York, set out to conduct a new meta-analysis of six existing studies. The pooled analysis appears in the journal Jama Internal Medicine. Studying intake of meat, poultry, and fish Jong and the team looked at prospective cohort studies that had been carried out across the United States, totaling 29,682 U.S. adults who did not have CVD at baseline. Of the participants, 44 percent were men, and almost 31 percent were non-white. Researchers had recorded the participants' dietary data between 1985-2002 and clinically followed them for 30 years, until August 31, 2016. Over a median follow-up period of 19 years, 6,963 adverse cardiovascular events and 8,875 all-cause deaths occurred. Of the cardiovascular events, 38.6 percent were cases of coronary heart disease, 25 percent were stroke events, and 34.0 percent involved heart failure. To define what constitutes one serving of meat and assess the participant's diet, the researchers used the Willett Food Frequency Questionnaire. One serving was equivalent to four ounces of unprocessed red meat or poultry or three ounces of fish. For processed meat, one serving consisted of two slices of bacon, two small links of sausage, or one hot dog, explained the authors. The median consumption in terms of servings of meat, poultry, and fish per week was 1.5 for processed meat, 3 for unprocessed red meat, 2 for poultry, and 1.6 for fish. Compared with participants with lower total intake of these four food types, participants with higher total intake, right the authors, were more likely to be younger and male, be non-Hispanic black, be smokers, have diabetes, a higher body mass index, BMI, higher non-high density lipoprotein, HDL cholesterol levels, and consume more alcohol, have lower HDL cholesterol levels and eat a lower diet quality diet, have a higher incidence of CVD and death from any cause. The main outcome that the scientists looked for was the relative risk of CVD and all cause mortality over the 30 years between people who consumed these different foods, as well as the difference in absolute risk over the same period. They calculated the risks for each additional intake of two servings per week. Up to 7% higher relative risk of death, CVD Jong and the team summarized the findings, the intake of processed meat, unprocessed red meat, or poultry was significantly associated with incident cardiovascular disease, but fish intake was not. More specifically, the increased relative risks of CVD and all cause mortality ranged from about 3% to 7%. The increased absolute risks were less than 2% over the 30 years of follow-up, add the authors. More in-depth detail shows that for every two additional servings of processed meat per week, the relative risk of all cause mortality rose by 3% compared with those who did not eat processed meat. The same was true for each additional two servings of unprocessed meat. The relative risk of CVD rose by 7% for every two servings of processed meat per week. For unprocessed red meat, this risk was 3%. An increase of two weekly servings of poultry correlated with a 4% higher relative risk, whereas fish was not associated with CVD risk. People who consume more servings per week would have greater risks, add the researchers. Study of critical public health importance The authors deem the findings of critical public health importance. They also note that more research is necessary to strengthen the findings. As it stands, the current study has some limitations, such as the self-reported nature of dietary data. This may have resulted in over or underestimation of the association. Secondly, the scientists did not have any data on the method of food preparation. Whether the meat was fried or non-fried may have impacted the health outcomes. Thirdly, the study only used one dietary measurement at the beginning of the study, but the dietary habits of the participants may have changed over time. Finally, residual confounding, the observational nature of the study, and the fact that the data may only be limited to US adults are further shortcomings of this research. Still, Jong and team conclude, the findings of this study appear to have critical public health implications given that dietary behaviors are modifiable, and most people consume these four food types on a daily or weekly basis.