 Oh, we're live. Okay, cool. And we're live. So please introduce yourself. Yes, hello. Welcome to the Bavarian Research Alliance stand. My name is Gabriela Blumberger. And I'm the project manager of a project called High Flow. It's a European funded project from Horizon Europe. And this project is about hybrid storage system, redox flow battery and supercapacitor technology. It sounds like very cutting edge battery systems. Yes. And the coordinator is Professor Pettinger. And the budget is, the total budget is four million euros. And what kind of discussions do you have here at the National Technology Conference? We're talking about proposal writing, what the Bavarian Research Alliance is providing. And many possibilities of proposal writing. We support proposal writing. And please introduce yourself. Hello, hi. My name is Panagiotu. Together with my colleague Gabriela, we are on the booth of High Flow on the nanotechnology in Thessaloniki 22. And I'm head of unit for ICT and engineering. And like this, we supported Professor Pettinger from University of Applied Science of Landshut in this project, High Flow, which is dealing on, like Gabriela told, on development of a hybrid storage system. The Bavarian Research Alliance is a governmental financed organization with a stakeholder of the Bavarian University and University of Applied Science of Bavaria. And we are financed as a non-profit organization by the stakeholder of the university and the Bavarian State Government to support the Bavarian researchers from academia and from companies on European projects. And like this, on this European projects, the Bavarian stakeholders need always international partners and on this conference and these booths like this, we look for strong and competent partners to bring them together with the Bavarian stakeholders to start initiate European funded project like this High Flow one. So, what is the High Flow? The High Flow project is a European funded project and is dealing on the energy storage on the hybrid system between, let's say, a Redox flow battery and a supercapacitor. It takes the advantage of both systems of the battery and the supercapacitor and put this in one joint system. Like this, you have a high flux of energy and with a supercapacitor and a high energy storage with a battery system. And what do we see behind you on the wall? What is happening here? Well, this is what we just told. This is about High Flow. And yes, it tells about the project itself and then also about the service from the Bavarian Research Alliance. So, there's high interest in getting to the future of energy storage as soon as possible with partners, with partnerships and getting things to the next level. In this project, High Flow, there are already 11 partners of all Europe with the coordinator of Bavaria, Professor Pettinger and the Bavarian Research Alliance and there's additional partners, for example, from the Czech Republic working on this project, on the high-age development hybrid energy storage system. And what do we see here on this wall here? This is another project. This is another European project. It's similar, let's say, to this High Flow while High Flow project is dealing on research and engineering. This TED Live is another instrument of the European horizon Europe where you have the possibility to make a network of PhD students, a doctoral network it's called meanwhile, this funding instrument and their funding... PhD students can attach and exchange within Europe and make common research. This, once again, is project TED Live coordinated by Mrs. Professor Köhler from the University of Bavaria. This is a university in the north of Bavaria and she initiated and coordinated this project with 11 partners and funded with 3.8 million euros. Do you think the batteries, the cutting edge nanotechnology and stuff to get things to happen is happening fast enough or can you push it? Can you make it happen faster? I think if you look now at the European Commission and these initiatives like the European Battery Alliance or the new battery partnership like the BEPA, the Battery European Partnership Association, the Commission in the last 2-3 years made a lot of challenge to push the networks between the researchers around Europe and to make research on batteries and even on other energy storage like hydrogen much faster than let's say 10 years ago. So it's fast but yes, sure it could be faster for the European community. And I guess the German auto industry is eager to see things happen faster in this business. Yes, yes, yes, sure. Now because the Bavarian Research Alliance is funded by the Bavarian government I would like to talk about the Bavarian automobile industry like BMW and like Audi and they already tried to distribute and develop cars on battery movement so they have e-mobility very stuck on and even the Bavarian government have some let's say regional funds to boost battery storage or battery movement. Alright, so anything else we didn't cover? You'd like to talk about? Do you have a lot of colleagues in this organization or? Yes, we have around 50 I would say. Around 50 we cover all areas. And do you participate in many events? Yes, definitely. Of course there was Covid so we had a lot of online events but we visited a lot of events, yes. Alright, cool. So I hope you have fun here the Nanotechnology conference here. Thank you. Short about the Bavarian Research Alliance because this is a very nice idea. The Bavarian Research Alliance funded by the Bavarian government and the Bavarian University always looking for international strong partners on the Horizon Europe project and like this we would like to get international partners and bring them with the Bavarian expertise where we had a lot of in Bavaria on hydrogen, on battery, on nanotechnology, on health, on environment. They bring them together. How would you say the nanotechnology industry has evolved recently? As we talked about for a long time and there's more and more things happening more targeted? Yes, more targeted and not so scientifically like in the last two or three framework program now the thematical area like nanotechnology or nanoscience is more implemented in some let's say areas like battery storage or hydrogen storage. It's not, it's more integrated and what we see is now we're going to have much more interdisciplinarity between different areas like biology, health, environment, energy and nanotechnology. It's very important. And when I look at this and it says redox flow, battery, supercapacitor technology what is the redox flow? Redox flow is let's say a new generation of battery different like lithium-ion battery and has a big advantage to have a big capacity and this project likes to let's say assimilate or bring out the disadvantage of a redox battery by attaching the redox flow battery with a supercapacitor which the supercapacitor is an energy storage system too has a possibility let's say to forward very fast energy but has another disadvantage this disadvantage of supercapacitor with a disadvantage of the redox battery will be assimilated by joining this in this project. And does it work? Yes. Put them together? Yes, yes. Professor Pending and the coordinator of University of Lancelot already had some good concepts and ideas. All right. And the supercapacitor used to be very low energy density maybe very fast. Yes. And now you can do more and more capacity in them. Yeah, by attaching them with a redox flow battery because the redox flow battery has a lot of energy but slow can bring out the energy very slow by attaching them with a supercapacitor which can bring out the energy very fast. You have advantages of two systems one development hybrid energy storage system. Sometimes I heard people dream to recharge the electric car in like five seconds but that's so much power, it's dangerous. You need to take the time to charge it not too fast. Yeah, five seconds is maybe too fast but five minutes it's reasonable and I think even now in the lab there are possibilities to recharge batteries in five minutes but it's always a question of its capacity. Five minutes of capacity of a thousand or only a hundred kilowatt hours it depends on the capacity, yeah. All right. Thanks a lot. Thank you. Thank you. Bye. I'm going to break for a second in the workshop. Introducing myself and the company. Yeah. Okay, can I just go for it? Yeah, please introduce yourself. Hi everyone. My name is Juliana Levada. I come from Santee which is the center of nanotechnology and smart materials. We are located in family town in the north of Portugal. We are a non-profit research center. We are dedicated to nanotechnology and technology transfer towards the industry. We are here in the nanotechnology conference for the dissemination of Biomatt. Biomatt is an European project that's being coordinated by Santee. I'm the representative of the coordinating team. Biomatt has the goal to establish an open innovation test bed for the production of nano-enabled, bio-based poly-retained foams and composites for the five top markets with the highest requirements for these materials which is building and construction, automotive and furniture embedding. Our consortium is built of 26 partners and we came together to explore sustainable alternatives for the production of bio-based foams. So our goal is to take renewable resources or low-value residues from industries such as agricultural and forest industries and use them to extract components, bio-based components for the production of foams. So placing high emphasis on sustainability, circularity and renewable resources. And then use those bio-based components to produce foams and then apply them to products such as mattresses, seat cushions, insulation panels, for example. Is it what you illustrate here? So here you have some of the raw materials that we use to extract the products. So here you have different types of rice husks that we use to extract silica, bio-based silica that we use as nanofillers to improve the mechanical properties of the bio-based foams. So as part of Biomat, we aim to establish, as I said, an open innovation testbed. Our catalogue of services will be quite polyvalent We will have 12 pilot lines dedicated to the pilot-scaled production of components and foams and as well as a range of horizontal support services such as LCA and LCC developments and establishments and product characterization, so we can cut it. Yeah, we can cut it. It's live. It's live. Sorry, I was on a roll and then... not anymore. Tell me. So these materials are in billions and billions of products eventually and that's the market, that's the target. Yes, because nowadays all poly-retained foams are produced using non-renewable resources, so petroleum-based products. Our goal is to reduce the non-renewable raw materials and substitute them with bio-based materials. That's one of the main focuses of Biomat. We are upgrading pilot lines to substitute the petroleum-based materials that we don't want to use anymore because they're non-renewable and substitute the bio-based materials to start implementing this innovation at an industrial scale and motivate the uptake of this innovative technologies at an industrial scale. These materials have the ability to be functionalised with appealing properties. So, for example, the nanosilica, nanobiobase silica can be functionalised to provide added properties such as flame retardancy. For example, here you have a textile that is non-functionalised so you can see that it was burned quite heavily and here you have an example of a textile that was functionalised with flame-retardant silica particles and you can see there's quite a difference between the amount of textile that was actually burnt and this one that did not. So, one of the functionalities that we are exploring is flame retardancy. The other two that we also are exploring is hydrophobicity and antimicrobial properties. For example, if you have a seed cushion or a mattress with antimicrobial properties can be quite appealing. In Biomat while upgrading these pilot lines to the production we aim to disseminate them and make them like current practice within the polyurethane sector. As one of the measures of implementation of the project is also the launch of an open tender which will launch at the end of this year and it will be appealing to SMEs, for example, that will be able to profit free of charge of all of the services that will have available in our OITD just by applying to the open calls within the open tender of our OITD. So, it will be good for the SMEs that will be able to provide profit from free of charge services and it will also be good for us as an OITD that will be able to validate and check that all of our products are okay and perfect to go to the next level of industrialization. More questions? Is there a lot of industrialization of nanomaterials or these kinds of materials? Is it just a continuation of what's been happening in the last 100 years or is it a brand new way of looking at things? Well, the nanotechnology sector has been growing continuously exponentially for the last few decades but right now the focus is on improving the sustainability of those processes and that is where Biomatt and of course many other projects and processes are being geared towards to improve the sustainability and towards of course the environment friendly processes associated with nanotechnology. Is it just working in chemistry or is it what are the experts in this field? What do they know? Okay, you have to think of this as a matter of scale because you have the developments on a lab scale and then as you progress in the scale up to pilot scale and then up to industrial scale the requirements are different. You establish the chemistry of it all at the lab scale and then the requirements as you progress in scale start being different. You have to maintain the chemical requirements while satisfying the upgrade of the technology and then you have other requirements that are regarding for example the reactors then you have the engineering and then other sectors come into play to guarantee the success of the processes. Because when you say test bed it sounds like a laboratory, it sounds like what you test. Open innovation test bed it's quite a new concept it was a concept that was introduced by the European Commission. An open innovation test bed is a number of entities that come together to provide a service a number of services and to... Sorry. Again. I was missing to provide access to facilities, that's the thing. Because if you think that an SME for example they might not always have easy access to a pilot scale reactor for the production or they might not have the knowledge required for the scientific development and that's where the OITB comes to help so to speak. So the OITB is a group of entities that come together to provide access to those services so to provide transfer technology and access to pilot scale facilities that otherwise might not have been easy to access to a small entities, an SME for example. So these groups of entities come together within a theme, a scope of research in the case of BioMath is a biobased and enabled polyurethane forms but you can find many others and the different entities with different levels of knowledge and technology will cooperate and collaborate to provide that service to another entity such as an SME. And then as we gather the different services within the catalog that you have available in an OITB we can then disseminate the innovation and the uptake of this new technologies that are the aim of the OITB. Because you really want to go from test bed to mass market. Yes. So this is a way to validate the technology. So in the scope of, for example, in BioMath we are able to provide services throughout the entire value chain of the polyurethane. So starting from the basic components, polyols, nanofillers, different components throughout the entire value chain up to the final product. And we can do that from lab scale, validation of technology up to the pilot scale production even in some cases depending on the scale of the pilot line even in the industrial scale. And then we can transfer that knowledge up to SMEs that can then implement them in their own facilities in their own companies and improve their services making them more sustainable, more renewable and more in line with the circularity of today's economy. And it's working all over Europe? Yes. So BioMath is a European project. We have 26 partners from all over Europe and we will be able to provide services to SMEs all over Europe, yes. And the discussions you have here and then the technology conference there's students, there's startups, there's professors, there's all kinds, right? Well, we didn't have the opportunity to discuss a lot because we arrived late yesterday but the idea to disseminate BioMath in this environment is of course provide our knowledge and our developments and also learn and absorb all the great developments that are occurring within the nanotechnology in the last year that's being showcased here in the conference. All discussions are very profitable and we hope to contribute also for the future of the young researchers here during this week. Indeed, very much so. So actually BioMath is already at its 18 months and last year we had our first in-person event. So yes, it's great to be back in person to share developments and share ideas face to face. It's a great new thing since the past couple of years in lockdown and talking to people through screens just like now. And right there behind you it says Yes, it's our website. We keep it up to date. We'll please visit. We have the catalogue of services that will have available on our ITB. All of the current developments, the information on all of the partners on our consortium, the objectives and the description of our project. And soon with the launch of our open tender it will be through there that you'll be able to apply to the different open calls. We can't wait to receive all of your requests. And on the video there, what kind of illustration are you showing? Can you tilt a little bit to the camera like this? So right now this is a video of the technologies more and more and more. Right now you can see a video of the technologies that you currently have at CENTI. CENTI is one of the... We are divided into five different areas. So smart materials, smart fibres, functional materials. I'm missing one. Never mind that. So, please just cut that part. It's a bit of a demonstration of the different technologies that we have indoors. So for the electronics and smart fabrication, also smart coating and the development of different materials. If you want to know more about CENTI and our technologies also you're welcome to visit our website. It's www.CENTI.pt. You'll have there a description of all of our ongoing projects and all of our capacities and technologies. We'll be happy to... And where is it in Portugal? So it's in Familicao, which is in the north of Portugal, half an hour away from Porto if you know it. Perfect. So a lot of cool stuff happening over there. Yeah. All right. So thanks a lot. You're welcome. What do you think? Thanks. That was cool. All right. Thanks. Me? Yeah. Something you forgot to talk about? No, I don't think so. All right. I even talk way more than I thought I would. Well, for the live chat, I'll put you in a break for a second. One second. Okay. So please introduce yourself. Hello. I'm Yoann Timon. I'm just an assistant professor in just Toulouse University, Port-Sabbaté. I'm just working in Syriam at Le Beaux-Touris. This is in the south of France in Toulouse also. My topic of my research is transparent conducting on thermal energy property of material and deposits in Synefem. So it is for purpose to invest energy, to convert thermal energy lost into electricity, useful also with transparent property or as a solution for future windows, future smart windows. Is it like energy harvesting? Yeah. Yeah. Of course. But the next level? Or what? No, just for the moment, I work on the material, precursor material like a deal of acid oxide and also copper iodide. We're just focused on two materials. So, for example, this one, which is a data for site compound, which is an oxide, which is deposited by sputtering radiofrequency. And also this one, copper iodide, which is deposited by sputtering classical sputtering. So. And do you have results? Yeah. Like does it work? Yeah. Just for example, we have just a good result for copper chromium. I will change my... Yeah. No problem. Is it secret? No, no, no. It's not secret. But this one, for example, it is the interest of this research topic. For example, the transparency in the visible range. And also when we apply temperature gradient, we generate voltage. For example, for our interest, we are just interested in material with copper. Copper is very interesting because we can generate p-type conductivity in multiple cases. For example, when we substitute copper one-push by copper two-push, or if we have the vacancy of copper one-push. For example. We can cut, maybe. We can just cut. And after that, Yeah, I will go to the result, for example. All right. So I cut to me right here. And then I'll cut back. We can start again. For example, just this type of synthium have a very good transparency in the visible range with good electrical productivity. Pretty good for p-type. But the factor of merit of this type of synthium are pretty good for p-type. Also, Subeck collision, the availability to convert it into electricity is a specific role for this type of material because it is constant. It's not dependent on the temperature, which leads to an interest for temperature sensor. It is a specific material which is very clearly adapted for temperature sensor and with very high accuracy. It is good for that. We have just enhanced the properties of this type of synthium material. For example, using laser, laser with these properties, we can modify and we can modify the properties of this material. For example, we can have transmittance of similar value but increase a lot of electrical conductivity. It is very interesting for future applications. For example, this type of treatment can increase the factor of merit of this transparent conducting material. It sees very innovative way, very low cost. It is very easy and also we have just very good result for p-type transparent conducting oxide through this new method. So you call it the PUCRO2? This one. It is dataforsite. Dataforsite is copper chromium oxide. And is it broadly available? Is it special or hard to find or easy to find? No, it is pretty easy to deposit. We can prepare with a mixture of oxide. For example, chromium oxide, copper oxide and also magnesium oxide for the doping. But it is pretty easy to prepare a target. After that, we just form the target to obtain a lot of synthium. The preparation of target is long but when we obtain this target we can make a lot of film with this target. And you present this here at the nanotextology conference. You do this presentation? Yes, it is my presentation for nanotechnology 2022 with the approach of synthium because nanotechnology is here in this synthium configuration because the thickness of this film is less than 100 nanometers thick only. But the surface can be here. For example, this surface is 2x2 cm2. Are there a lot of people going in this direction or are you the only one who figured this out? No, a lot of people work on this transparent conducting thematic, but the innovation in my case is to use and to study the thermometric property. The fact to combine both is a more early report in the literature. But it's a new way to overtake some difficulties for the future. For example, to arresting some energy from exterior, from energy rest to in the future reload your battery, for example. But you were talking about wind? For wind? Windmills? What are you talking about? Just heat. If you have a difference of temperature from inside on wood side, for example, during the winter or inside it's hot on wood side it's very cold. If you have this difference, you can have a thermometric effect. Also, it is possible when it is very sunny. From the sunny, we just eat the same thing and generate also thermal gradient which can generate voltage. In terms of the energy harvesting it's been talked about for a long time. How much has been done so far? Like there is a solar and wind, right? That's big. But how much of the dream is real? Yeah, it is an intermediate dream. That's an intermediate duration because of course to this day it's not finalized or optimized because it is very innovative way. But it also has some possibility to combine with the photovoltaic effect, for example. With the photovoltaic, thermometricity becomes more interesting. Do you have some nice conversations here? I developed a technology show. Of course, for example with graphene, new structure, a lot of things because there is a lot of photovoltaic properties. Of course for me it's interesting to discuss with my colleague about new material, brand structure to optimize eventually the adaboration route with new route. For example, this route with the fast laser annealing which is more and more used in the laboratory for new material but also in the industrial field. And what is the most interesting thing you heard at this conference? There is a lot of things. For example, today, an eminent professor just talked about graphene, a bond structure of graphene with tilting. It is very interesting because it's new property. We can have new electronics. Maybe it will be used in the future to couple with other properties like this. It's very interesting. And over there in Toulouse, there's a big connection with the airbus. Of course, how? Can I cut? Because I want to cut just to make this one. Yeah. Or Toulouse, it's okay? Yeah. Toulouse, of course. It is a big city for airbus company because the final assembly of airplane is given in this city. It is also a pink city. It is a very beautiful city. It's not so far from Paris. It is in the south of France with a good weather. Also, my laboratory is labelled as a Carnot. It is labelled as a Carnot with Montpellier. It is an institute called Carnot, chimie balance remat. And they have a lot of various fields as a battery, supercapacitor, gas sensor, of course, transparent conducting oxide on the terminal of the city and a new field like hydrogen. We have a lot of various techniques like sintering techniques, spark plasma sintering, but also through new printing on the DLMS. DLMS is used as a laser to make three metals, but also new ceramics and new functional ceramics. I work also in this thematic. And also new routes like winder jetting, winder jetting to make 3G material. It is a laboratory which targets a lot of the elaboration of material. New material for the various functionalities. And many people there? There are four sites. There is a lot of sites in this laboratory. There are about 200 people. But this university is very big. It is a second... In terms of number of students, it is a second university in France. There are a lot of students, more or 30,000 people on this site. It is a very large city. It is a very large student city. Cool. Thanks a lot. Thank you very much. You get something. Yeah, yeah. You will assemble? Yeah, we'll assemble. Thank you very much. In the chat I'll put you in a break for a second. Thank you. We're back right here. Hi, so please introduce yourself. Hello, my name is Vittorio Rafa. I am assistant professor of molecular biology at the University of Pisa. And what kind of conversations do you have here at the nanotechnology conference? Well, this is a really nice experience to be here to introduce to my colleagues the research outcome of a big consortium working in the framework of IGIN Project. IGIN Project is a project funded by the European Commission in the framework of FET Open Call. And let's say our research field is trying to apply advances in the nanotechnology field to the field of genome editing. So, it's possible to edit the genome? Yes, of course. And I should say that genome editing with the discovery of the CRISC-9 it's a bigger revolution in the biotech. Just to tell you, give you some example, I'm pretty sure that in a few months we have gluten-free crops, for example. So, it's a bigger revolution in the biotech. However, if you focus on the therapeutic applications we are far from reaching our milestone. It should be to have such molecular shifts for treating every disease. We still have problems related to delivery of this machinery for genome editing and we have also issues related to the safety of the treatment. And what we believe and it's related to our research field is trying to use nanotechnology to overpass these issues and these limitations related to the safety and delivery of the CRISC-9 machine. You said... how do you say it? It's CRISC-9. It's a molecular shister. You can design this molecular shister for targeting a specific locus into the DNA and cleave these locus and have the genome count. That's wonderful because it means that we have a tool in your hand that can, let's say, make the difference between health and disease but which is the major point. The major point is that this system is able to recognize even a low frequency also sequences that are similar not identical to the target. And so this can cause unwanted cut in the human genome. So this is dangerous for the human genome. This is why there are some limitations, there is no concern in applying this technology to humans. When you say you were talking about the crops that will be coming in a few months, why is it so much easier to do these crops than do some medicine that just makes everybody healthy? The difference is that if you cut one unwanted point in the genome, the crops, okay, that's not dangerous for the human health. It should be not, okay? But if you give this medication in the current version to humans, you couldn't, let's say, predict to have cut not only in the wanted site but also in unwanted locus. And this could be very dangerous because if you cut the human genome in a wanted, let's say, point, you can create disease rather than carrying disease, okay? So what we want to do is to use nanotechnology to create a nanoformulation, this Criscats 9 system. And for doing this, we use plasmonic nanoparticles. So why plasmonic nanoparticles? Because they allow us to generate a system which is light switchable. And we have a specific application in mind which is used as a light switchable system, nanoformulation, Criscats 9, for treating, for example, melanoma lesions. Is it possible that there's something deeper than the genome that we don't know about that could be the challenge right here? Or do we know what we're looking at and it's just a question of putting things together in the right way and it starts revolutionizing everything? I think that the point is that we know very well the human genome, but the human genome is patient-specific and what is important is that you have a personalized medicine. So you should focus your treatment to specific patients, to specific lesion and to have a system that is light switchable allows us, for example, to give this system as a cream, as a nanoformulation, the lesion, but we can use the laser to, let's say, activate this medication just in the melanoma cancer cells. And so this doesn't affect the healthy cells. So the dream, the big dream in nanomedicine is to have a new generation of medication that don't have side effects. Okay, so this is the point. The point is not really the human genome but to have medication that are targeting to the cancer cells rather than to healthy tissue. Some people will have a bad case of cancer. They don't really care about the side effects, right? But you still have to take it slow? Yeah, that's not totally true. I should say that we have a lot of medication for treating cancers but sometimes the side effects are too strong that you really impair the quality of the life of these patients. This is why these patients sometimes refuse this medication because it's said to say, but they say, I want to have the last year for a month of my life and feel, let's say, well, not to have this medication. So side effects are equally important. We should, this is the, let's say, our milestone. It should be our milestone to have, in my opinion, a smart medication. For example, one possibility and this is what we are trying to do for the future is to give this medication in a... Sorry about that. Please, if you can continue. Yeah, I was telling you that the opportunity that we have thanks to the nano-medicine and the new advanced nano-medicine field is to generate new medication which are stimuli responsive. What this means? This means that you can give the medication in a form which is not active. So it's not dangerous for the health of the patients. Then you can activate this formulation just in the lesion or in the pathology side. This is what we are trying to do. We want to develop this nano-formulation for genome editing which is not active. We would apply this as a topical cream onto the lesion. Then we want to use a laser radiation which is a focus set and specifically designed to activate this killing formulation in the past in the cancer cells. This could be an improvement because it's, let's say, a formulation specifically targeted to the cells but without possibly side effects on the healthy cells. So do we have nano-medicine? Does it exist in a broad scale already? Or is it still something people dream about and it's still trying to reach it but it's not right? That's not a real dream. I should say that we use Plasmonic Nonoparticles for several applications. For example in diagnostic or for example for laser ablation. So we have them and we have them in clinical trial. But now what we want to do is to use them to generate, to conjugate them to the enzyme responsible for genome editing and so trying to design both the nanoparticles and the laser radiation in order to generate, trigger the activation of this nano formulation. So that's something that it's a technology that is mature. I should say that time is ripe for this technology and it still needs validation in the lab before reaching let's say scale production or let's say market analysis. So how far? Well, IGIN project will finish in two years and half and in this time we expect to validate this technology on a mouse model which is relevant of the human pathology. So this will be our starting point to seriously think how to use this for exploitation. So to exploit this technology for market application. And how many targets do you have? How many diseases is this going to result? Well, because of the use of the laser of course treating the skin is simple because it's accessible. But in our view this is not the only application possible. For example, it could be very interesting also to treating eye lesions again because the retina is accessible and so for sure this could be another application and in the future why not we can also think of this application by using a laser that are stereoscopically implanted for treating indeed the tissue. But this is not the first let's say application in my opinion. For validating, for proof of concept studies my opinion is better to focus on tissue that are accessible like human eye and like skin. Because this simplifies the design how difficult is it to rewrite the genome? Well, we have a lot to learn but a lot has been done. You know that Charpentier Don was the winner of the Nobel Prize for this discovery in 2020 and after this discovery even after the Nobel Prize they are doing a lot to teach us how to use this amazing tool. So I think that our task is to make better use of the potential of nanomedicine and so to merge advance in the nanomedicine to the recent discovery in the field of genome editing to create a new generation of medication. I call this programmable nanomedicine which means in my opinion is to generate a nano formulation that you can activate according to the needs, according to the outcome and the output that you expect. So I should say that the technology is mature but what is important is to bring all together and to let's say fuse the outcomes, the big advances that we got in the last year in the two fields to propose a new solution. Where are you going to program it? Is it in a lab somewhere or is it possible that there is a little device for people like the doctors might get or maybe even at private people's homes that can program something and then you take it? No, our idea because the laser technology is well used for example for cosmetic application or for laser therapy so what we have in mind is to redesign this technology that already exists for other application and customize for our specific application. So for sure we need to educate a new generation of medical doctor because they should handle nano formulation, laser radiation but I should say something that we have already in the field for different application. Do you see any criticism? CD burner. So I don't see big criticism on that. So it's to take something that exists, switch it around and boom, use it for your application. More or less, more or less. That's you have a different component. You have the Grisgas 9 system that already exists. You have the Plasmonic nanoparticles that already exist. You have this laser radiation that is important that you engineer this system. You should perform a rational engineering with this system because you understand which is the good, the laser which power, which intensity which frequency. Spalcedo continuous mode in order to irradiate these Plasmonic nanoparticles and now these Plasmonic nanoparticles react. They generate eating and this eating should activate our recombinant protein. So something that could be done and we demonstrated the single pieces working but what we should now is that they make the system working. That's the point where we are. So you said two and a half years was something and then the next step. What do you think is who do you think are the best in the world? In this field. Is it at the pizza? I should say that with this fat open project we are the first to propose this light switchable nanoformulation of gene editing. So actually we don't have competitors on that. But we have a lot of teams testing different solutions. For example there are teams working on light switchable proteins. They are not, let's say, the light switchable it's not just used by nanoparticles but by specific protein domains. It's another approach but I could say in my opinion of course I'm a fan of nanomedicine. Compared to the other approach, nanoformulation is a double advantage because with the nanoformulation what we observed with this nanoformulation is that the medication this medication is able to spontaneously cross the cells to spontaneously reach the nuclei so we don't need any delivery system. The other system needs the viral vectors to express this machinery we need to use a lipofection, an electroporation and so we don't need any transfection tool because thanks to the nanomedicine this medicine is able to spontaneously cross the membrane and reach the target which is the DNA into the nuclei so there are other approaches in the literature but in my opinion our approach is superior because of the superior properties of nanomaterials. How does it do that spontaneously? We investigated the mechanism involved so nanoparticles inside are similar to viral particles so I should say the cells is used to interact with such dimension and so what happens is that when these nanoparticles approach to the cell membrane they spontaneously internalize it in this specific case we found two different mechanisms one was endocytosis the other one was passive diffusion but the cells have a strong tendency to internalize this nanoformulation then the nanoformulation passes into the cytoplasm and then thanks to a nuclear localization domain which is present into the protein can pass into the nuclei and identify the target the genomic target where to heat to perform the cleat but this is thanks to the nanoparticles because if you give if you provide this enzyme without the nanoparticles you don't see any ability to cross the cells so you should perform for example viral transduction but you know the use of viral vector in humans has been tested for several years in several gene therapy projects it rise ethical concern so I'm not an expert in creams but is it possible that the skin is the biggest organ we have in a body and if you put some cream it might target something that's deeper no, we have the opposite problem the skin is a barrier and so one issue could be related to the penetration depth okay, so there is the possibility that penetration depth is not satisfying if this is going to happen I don't know we are still in the testing stage but if this isn't going to happen we have an alternative solution which use trans transdermal micro needle that you can use like patch to micro inject the solution in let's say in thickness which is more or less 1 to 300 thick under the skin and this is just a plan or it's already being done no, this is not done by me but there is a colleagues in the University of Pisa Professor Giuseppe Barillaro that has several projects testing this micro needle in different projects for different application and in my opinion this could be also a good plan for our technology to let's say use these devices that have been developed from different application to use for our application so let's say this is a plan B just in case penetration death or non-formulation is not satisfying of course when you run a European project if you want to be successful you should have plan A plan B and plan C you should understand which are your risk and also plan your remediation actions and this is what we are doing and I was doing a video with a professor he was talking about the teeth you could maybe have that as a delivery mechanism or also the oral application what is accessible by light is a target for this medication what is inside the human body is not accessible it requires a laparoscopic intervention and we should avoid this stage but what is accessible by light it could be one target for our technology I would also say in this European project there are three companies involved which are ProPremia, Lyon, XM2 and why we are involved we have also just another academic consortium which is the Institute of Italian Technology so we put many companies in this small consortium because really we want to increase the technology reading at this level of our technology can you explain a little bit about those three companies? are they like startups? one is a medium science company the other are spin-off I guess I'm not sure about that I'm sorry with my colleagues I made a mistake but what I can surely say is the ProPremia surface is a top level company material science so they have expertise in a standardization of these gold nanoparticles technologies gold nanoparticles in order to optimize the surface properties for market application so they are in charge of the standardization studies for a future marketing of this nano formulation then we have M-squared which is another company from Scotland their business is a laser so in our project they are responsible for the design of the optimal laser radiation which is customized for our specific application and then there is Lyonix which is a company in the Netherlands they are excellent top level company for microfluidic chip why microfluidic chip? because let's say we want to propose not just a therapeutic application but also biotech application in any lab in any molecular biology lab there is the need to perform the genome editing of cells because they are modeled for studying human disease and there are many applications on that so what we are building or what the Lyonix company is building is a microfluidic chip that integrates with the laser radiation in order to have this disposable system where you can edit the cells and use these cells for bio research and here the nanotechnology conference you have some good connections oh well I am active in the nanotechnology field since I was a PhD student so of course there are people I am still in contact with them but what I like the most is there are many new research line especially in the bio electronics in the plasmonic nanoparticles in the material science so I think that conference like nanotechnology could be the optimal chance to have new connection and to bring in our consortium those competences we miss and then we can make the difference for a future commercial exploitation of technology this is why they said to be here because it really is a multi-disciplinary forum with expert from different disciplines and our project is very multi-disciplinar little ranch here competence molecular biology and medicine and microfluidics and material science so we need to have let's say multi-disciplinary approach and for sure here we will find multi-disciplinarity and without getting into politics as a chance Europe will be in front of the USA and China on this segment oh my gosh that's a difficult question I can tell you that we protected with the patent that has been granted our technology so it was granted by Epo this necessarily means that we can compete with such big big field I should say we are doing what is in your hands in our hands I mean a patent is technology to have the company that are able to produce the technology into the consortium since the beginning so I think that we have the good ingredients to be successful that's what I also thanks a lot your time was a big pleasure we didn't forget to talk about something no I think that's all thanks a lot alright thank you very much I'll put you on a break for a second in the chat good afternoon ladies and gentlemen this meeting was organized in order to have this general assembly of nano net research and innovation network is an international network most of you you know about this one we have several general meetings I think the last one it was of course in 2019 Antonius you have made also one in last year okay sorry okay it was the last one in the last year I think we draw this one in 2020 so every year actually takes place here in nano technology one of the days usually Wednesday like today this is some of a general let's say of the day you receive this one earlier previous days and possibly today some of you some new people who promotion new collaborations participation in new networks research and innovation project European or international and how to in general to increase and improve the growth of nano net society with new members activities of course so just to remind to most of you and some others who are new in this era of I mean in this nano net activities started in 2003 from the Nanotechnology Lab and Aristotle University of Thessaloniki initially it was to coordinate activities within the university if it was possible in the area and of course after all these years almost 20 years now you have 20 years exactly to the this nano net activities extended from the area to the country and Europe and through these conferences and through these activities around the Nanotechnology Lab around the other let's say association like Hoppe came to let's say collaborations and attract members from all over the world especially during this conference so nowadays we support somewhere 670 to 680 members and the scope of course is to bring together from the very beginning to work to bring together people working in the area of nanotechnologies and nanobio technologies in academia, research industry in hospitals with consulting working together with consulting companies working together with companies which exploit the results of research let's say and of course to try to organize activities to inform local people governments and all policy makers about these technologies about the results about the solutions so the organization you keep the organization almost let's say unchanged during the years but simply you add something new things new wording let's say in the legal, ethical health safety this is the horizontal clusters and this is the vertical clusters few things changed during the years maybe sometimes you may change something more here or you have more let's say vertical clusters and this in order to be done you expect your ideas this meeting is the proper place to hear new ideas even about the clusters about the interest about how to renew all these organizations but this give us the opportunity people who work in the field depending on the vertical or this horizontal cluster to have one classification if you go to change will change many things so you usually expect to see if there exists some new era for example if you extend for example nano biomedicine with bioelectronics also you have made in 2019 I think this is from 2019 simply today you have one new responsible Elize he used to come to this nano technology meeting the last 10 years Elize or something sorry 10 years almost yes I think it was 2011 or 2012 so it's almost 12 years and she will be the proper person in order to be responsible for this let's say cluster with her ideas and this is the people working already are responsible and starting from the first one Yanis also is responsible for South America you will see later I think change since 19 dramatically and the connections also stop especially with Asia but even with North Asia now the last year and this year open of course in Europe and some connection from United States you can see during the days also people from United States but people from Asia is missing and people from Brazil for example are also missing but nevertheless Yanis is also responsible for there but other people some of the people now of course are during this time are which are possibly Spanish now are in other let's say workshops so they are here but more or less Yanis Kalits also here Nano energy and also this area is active especially for energy and for environment and give more attention to the area I don't know if you not here but the two nano net and more or less again this version is the oldest version I correct few minutes ago but still it's some numbers it's older but nevertheless members comes mostly from Europe are more than 500 members from Europe and then around 50 to 60 is from United States Asia from this area and some others from other overseas areas but you can see also that comes mostly from academia research some 160 some 170 companies consulting companies and 10 to 13 hospitals the subject are of course more or less I mentioned what is the vision of this nano net what is the mission what do you want to and what you offer and of course what are the work the deliverables or the work we have to do of course there is no membership for good and for bad for good for good gave some continuation of the last four or five years ago from European Commission they wonder how you succeeded to continue 20 years almost one organization and then they try to interview why how usually the associations or this kind of cluster they have life of three or four or five years which is almost the life of funding from some organization usually public and how happen this one we know more you know also that some money this partner even if you account 100 euro per year you will spend the effort to get money than the real value so you have to find another way and we find another way okay and of course the services when you the services you provide it's less than the services you provide when you paid so you have some a manager to keep all going and try to to give some information from services and find a solution through let's say collaborations through collaboration in European projects in the national projects supporting this event of nanotechnology so it's more free no payment but you have some job to do so to coordinate activities to inform the members of the referer already to promote any kind of partnership mobility etc to identify the challenges and solutions and disseminate exploit and to facilitate and promote of course it's clear that during the years the companies we once a few in this cluster this network but with the time since you have a lot of applications the companies come one after the other and today you have as I mentioned earlier around 170 and the new members it's I would say mostly related to new companies during the last few years and less people from academia labs and other associations so this is the numbers and statistics but I will move faster a lot is this one organization of course is Hellenic Organic Community Engineering Association established in 2011-2012 the good thing to this is first of all it printed electronics related to organic semiconductors the good thing is that even that is national Hellenic Greek Association connected very easily with other associations like the Affelin the France the German the organic electronics action Japan Canadian Korea Chinese and something of course nano net connected with this second Germany Germany has two association now changed name and integrated in micro electronics in the same region of North Westphalia but bring together all other associations and help nano net to come together or to especially in relation with companies because this association refer to HOPAA and the others refer to companies in this new era of organic semiconductors or applications comes from this era so this and of course is an independent and survived the years and give us also the opportunity to learn how to get money for funding for example European Commission of course this involves this association master degrees and organized together with HOPAA these events of nanotechnology members of I have to say the members of nano net also are members of societies international committees scientific committees in these three international conferences and the schools or some of them they are teachers some let's say responsibilities of some of these people of nano net when meet here in this conference either to serve giving this lecture to help or to advise in the conference the specific new participants coming in the field especially young people because you don't know the young people nevertheless this is the organization this is the way that we succeed year by year and of course also support the nano net together with HOPAA and the lab support another activity and this activity is related to another conference take place every year in Athens not in Thessaloniki in October every year this October will be either 10th or 17th of October and all together each of them supports the other how work they work in collaboration to submit proposals and here are some of the proposals submitted from the members of this nano net network during the years some European but also some national if you talk about national activities this is year by year so here inside of this members for example 16 members in this martronics it was a project of course ended 5 years ago you can see several members which are members of nano net or are members of HOPAA or are members of this association I mentioned earlier coming from Germany or France so if I continue you will see many members depending of okay this is for example for nano medicine this is for batteries or for manufacturing so many partners this are all ended but we have some already you can notice here that HOPAA participate in this activities some other new like the around many partners of this of okay also the nano it's another project coordinated by this is the of working and trying to extend activities and at the same time to gain knowledge increase portfolio services opportunities now is for example the new funding cooperation opportunities through the recent innovation European projects within Europe horizon Europe 21, 27 already two calls one and a half they finish almost in the end of the second year 2022 2023 but the next coming soon they will announce in few days the final let's say contents of calls for 2022 to 2023 especially in cluster 4 which is related to digital industry in Spain for example there is some calls like or for cluster 5 which is related to climate and energy and mobility there are some specific calls here but of course there are much more which are related to our subjects to subjects deals with nano net now within our activities of course it's all of us to find some ways to understand where things are going or much better for example there are some challenges where our technologies can offer some solutions for example agrivoltaics a new era which are developing more than 40% year by year and this gain our attention because energy, lighting for example sensors biosensors play an important factor in this era of agrivoltaics what is agrivoltaics? Agrivoltaics means agriculture plus voltaics plus energy the new energy so if you bring together these two you understand that you have this new era of agrivoltaics it's new terminology in literature you will find this as agrivoltaics by 95 to 96% of publications others are referring to a bit different way but nevertheless the major terminology today is agrivoltaics agrivoltaics new energy and mean photovoltaics so this is the meaning of this special workshop we will decide to have next day, tomorrow afternoon even in a session and you hope to have a longer activity during the next year at least to have a workshop of one day together with the workshop in Isfoe which is related to organic photovoltaic perovskites photovoltaics but also you are planning to have a half day or even a one day conference an exhibition in Athens next October so nevertheless tomorrow we bring to your attention this conference where you will introduce some main activities actions I think it's quite important for this audience because all the technologies especially those related to flexic or organic electronics are related with energy lighting which is necessary for extension of the photosynthesis especially in areas where they have dark days short days while the energy needed every day especially in summer in places where we have a lot of light high sun shining areas with high temperatures or for areas where we have cool weather in any case energy needed every time every minute in order to have a smart let's say greenhouse a hydroponic greenhouse and this is the subject of this activity and you think that you will have next year a huge activity and solutions and relations because related not only to energy not only to light but also to land because you want to have same land for several reasons not only for production not only for energy but also to reduce water to increase the food etc. to reduce the CO2 emissions etc. So this was I mentioned earlier and I referred to Professor Mr. Lies that he was responsible also from Mexico and South America after 19 you stop activities with some areas especially with areas of Korea, Japan China you see here difficult to continue these activities actually we think many people for many years will reduce activities and collaborations and traveling in China especially so you want to see how these things will be extended so that's all for me and you may return back to main agenda it's open actually to discuss some details and to hear you some comments on that or to add something maybe something who you don't know or you didn't realize the person is this one please remember or ask them of course you want to see these people to work to this direction so this is the agenda of course this is my presentation try to present all things not only for old members but new comments or people who may be interested to participate and now you have some general open discussion please take the opportunity to comment first of all to give your ideas thank you and you've really assisted in the development of nanotechnology in an amazing way the first time that I came to this conference you told me that nanotechnology could bring life to the economy of Greece and that it could change Greece and you have been true to that mission and the things that we see here are beautiful beautiful fruits of the things that you have planted and I'm so proud to know you so I want to be very clear about that before I say anything else because this field is growing rapidly and you have been instrumental in making that happen and making it happen in Greece which might otherwise be an improbable place for it and I think that's really marvelous it's really really really cool so what I was looking at in this list is there's the sort of almost random events of people having funding for projects and as you say they last a few years and then they don't last nearly as long this group has lasted a long time I'm interested in examining the challenges and the possible solutions and I'm interested in taking our legal safety and health and ethics group and leading spearheading and effort to bring together information from what has been accomplished in order to really look at what the challenges have been and how the things we've accomplished could offer solutions as you know with nanotechnology can solve most problems if we think about it really carefully and if we weigh the costs and benefits I would like to offer for this first of all I had some very good luck this year you know that I'm now at Georgetown University in the Global Health Law Program and I was invited to speak in the Embassy in Haiti in Washington because last year I had invited six Haitians for a nanoprogram and on scholarship I love them scholarships the European Scientific Institute was somewhat hesitant about whether they could have connectivity and meet their standards and they did very well and the ambassador congratulated me personally and wrote a letter to the institute thanking them and said to me ma maison c'est chez vous and he offered to me the Embassy of Haiti as a venue for any conference I would like on technology and what I'm thinking is because we don't have many French speaking affiliates and we don't have all that many Caribbean and that area and I do have very strong contacts in Brazil you know I've been a few times to Brazil for the McKenzie School of Law Program and nanotechnology why don't we think very seriously about this patch of bringing together what we've done looking backwards perspective but using it to look forward to protect posterity and to take these things that we've done and craft solutions we have a new venue that is open to us because the ambassador I believe was quite sincere because he spent a great deal of time with me asking a lot of questions and let's do something with this we also have a lot of money because we have the venue we have marvelous technology such as Nick and Alpha View so we don't need to ship everybody to Washington or Haiti or whatever we can bring the Brazilian group from McKenzie and we can bring in also the Center for Biomedical Law in Portugal who you know doesn't have this kind of nano staffing but does have medicine and public health University of Cleveland and let's do this let's bring together these people and ask these questions that are very important they may not be hard questions but we haven't asked them yet and let's see what solutions we can come up with making double duty of what we already know and I'm sorry I talked so long but there's a lot of people that we can bring into this who else I'll send you an income remember it here okay