 The study found that the levels of TNF-alpha in patients with septic shock were significantly lower than those in patients with endogenous intoxication or abdominal sepsis. Additionally, the level of TNF-alpha in deceased patients was even lower, suggesting a decrease in the ability of monocytes to produce pro-inflammatory cytokines in response to endotoxin aggression. Furthermore, the level of perception increased with each stage of the disease, indicating the presence of CD14 receptors on monocytes, which are capable of converting them into endothelial progenitor cells. These findings suggest that monocytes play a key role in the pathogenesis of generalized peritonitis, GP, contributing to the regeneration and restoration of endothelial function during the development of this condition. This article was authored by A. R. Sariv, S.H.K. Nazarov, and S.G.A.L.I.S.A.D.