 Globacan 2018 data shows that colorectal cancer is the third-deadliest and fourth-most common cancer worldwide with nearly 2 million new cases and 1 million deaths expected in 2018. The rise in incidence is attributed to factors such as obesity, sedentary lifestyle, red meat consumption, alcohol, and tobacco. However, advances in early detection screenings and treatment options have reduced mortality in developed nations despite growing incidence. Genetic testing and family history documentation can help those with a hereditary predisposition take preventive measures while the general population can reduce their risk by consuming less red meat, alcohol, and tobacco and more fiber, vitamins, and minerals. This article was authored by Prashant Rala, Tagore Sunkara, and Adam Barsouk.