 Whole exome sequencing and bioinformatics analysis revealed that causative genes for ocular diseases accounted for the highest proportion of genes with high pathogenicity in HM patients, while for pathogenic gene mutations were identified according to ACMG guidelines. Additionally, three causative genes for neuropsychiatric disorders were found at the HM locus, suggesting potential interactions between these genes in HM and neuropsychiatric diseases. This article was authored by Yang Liu, Yang Liu, Wen Zheng, and others.