 This study found that employees' perception of workplace policies and measures during the COVID-19 pandemic was associated with their health-related quality of life, HRKOL. Employees who perceived more comprehensive, timely, and transparent workplace policies and measures were less likely to report poorer HRKOL. Additionally, the study also showed that employees' perception of infection risk partially mediates the relationship between workplace policies and measures and HRKOL. Therefore, it is essential for employers to provide adequate and effective workplace policies and measures to ensure employee safety and well-being during the COVID-19 pandemic. This article was authored by Eliza Lai-Yu Wang, Kai Fai Ho, Samuel Yeung-Shang Wang, and others.