 Our study found that the Egyptian approved vaccine, the Sinopharm vaccine, BIP-CRV, was safe and effective in protecting healthcare workers from COVID-19. We observed a 67% vaccine effectiveness against symptomatic positive PCR cases, a 0.45 lower incidence rate of hospitalization in the vaccinated group compared to the unvaccinated group, and a significant decrease in work absenteeism among the vaccinated group. Additionally, most adverse events were mild and well tolerated, and no sentinel adverse events were reported in pregnant or lactating women. This article was authored by Rasha Ashmoui, Ehab Kamal, Waigdiamine, and others.