 This study investigates the coverage of human papillomavirus, HPV, related information on Xihu, a popular Chinese social media platform, using user-generated articles collected by a Python web crawler with keyword searching. The final sample included 115 articles covering a two-year period between 2017 and 2018. Results showed that most of the articles reported HPV's relationship to cervical cancer, HPV severity, and vaccination benefits. Thematic framing was more often used by Xihu articles to disseminate HPV-related issues, and a significant relationship between framing strategy and information coverage was found. The study suggests the need to communicate comprehensive and detailed knowledge about HPV vaccination on Chinese social media.