 The receptor for advanced glycation end-products, RAGE, is a protein found on the surfaces of many types of cells, including those in the lungs. It is involved in recognizing and responding to certain substances in the body, such as proteins and sugars. When RAGE binds these substances, it can trigger inflammation and other responses in the body. In the lungs, RAGE is mainly found in alveolar type I, ATI, cells, where it helps regulate lung function. Disrupting RAGE levels can lead to lung diseases like cancer or fibrosis. Additionally, the presence of soluble forms of RAGE, known as SIGE, can indicate damage to ATI cells. Despite its importance in lung health, the precise role of RAGE in the lung is still being investigated. This article was authored by Stephen T. Buckley and Carsten Ehrhardt.