 Retinal ciliopathies are genetic diseases characterized by defective cilia function, leading to progressive vision loss and blindness. In this study, researchers used a high throughput screening method to identify potential drugs that could be used to treat these conditions. They found that one such drug, resurpine, was able to improve the health of photoreceptors in both mouse models and human patient organoids. This drug was shown to restore the balance between autophagy and the ubiquitin proteasome system, which may help explain why it works so well. The results of this study provide hope for developing effective treatments for retinal ciliopathy patients. This article was authored by Holly Wai Chen, Manju Swaroop, Samantha Papel, and others.