 Lycan simplex chronicus LSC is a challenging skin condition with no clear treatment guidelines due to its multifactorial nature. A systematic review found that topical corticosteroids are the most effective treatment, while other options such as immunomodulators and antipraritics show limited evidence. Novel therapies like transcutaneous electrical nerve stimulation, focused ultrasound, and phototherapy also show promise but require further research. High-quality studies supporting LSC treatments are lacking, highlighting the need for larger controlled trials. This article was authored by Michelle C. Hoyes and Sean G. Quattra.