 Tissue engineering materials and processes are needed to provide optimal scaffolds that meet the biological demands of tissues. This paper demonstrates the influence of chemical surface modification on the biological performance of poly, caprolactone, slash pristine graphene scaffolds for bone tissue applications. The results show that the addition of pristine graphene has a positive impact on cell viability and proliferation and that chemical surface modification leads to improve cell response. This article was authored by Wei Guangwang, Guilherme Catano, William Stephen Ambler, and others.