 This study examines COVID-19-associated rhinoorbital cerebral mucomicosis, ROCCUM, in India during the second wave of the pandemic. The study found that Gujarat and Maharashtra had the highest number of ROCCUM cases, with a mean age of 51.9 years and a male preponderance. Diabetes mellitus was present in 78% of all patients. Most cases showed onset of symptoms between day 10 and day 15 from COVID-19 diagnosis, with 56% developing within 14 days. The treatment included intravenous amphotericin B in 73%, functional endoscopic sinus surgery, FES, burnousal sinus, PNS, debridement in 56%, and orbital exentration in 15%. At final follow-up, mortality was 14%. The study concludes that corticosteroids and diabetes are the most important predisposing factors for ROCCUM. Early diagnosis and initiation of treatment with amphotericin B, aggressive surgical debridement of PNS, and orbital exentration where indicated are essential for successful outcome. This article was authored by Brittika Sen, Santosh G. Honawar, Sabyasathi Senbukta, and others. We are article.tv, links in the description below.