 A recent study has found that rare protein-coding variants are associated with operational tolerance in a significant number of patients. These variants are located in three genes Homer2, IQCH, and LCN2 which are all expressed at the primary psyllium, IQCH structure in immune responses. This finding has important implications for a better understanding of immune tolerance in transplantation and other fields of medicine. This article was authored by Anik MassArt, Anik MassArt, Anik MassArt, and others.