 This study investigates the shared pathology between COVID-19 and osteopritis, OA. It identifies 83 overlapping differentially expressed genes, DEGs, which are then used to construct a protein-protein interaction, PPI, network, transcription factor, TF, gene regulatory network, TF-micro-RNA regulatory network, and gene disease association network. Based on these networks, several candidate molecular drugs related to hub genes are identified. These shared pathways and hub genes may provide new ideas for further mechanistic studies and guide more individual-based effective treatments for OA patients with COVID-19 infection. This article was authored by CE Chen, Wen Huan Wang, Hao Zhu, and others.