 The blood-brain barrier represents a hurdle for the delivery of therapeutics in brain tumour tissues. Here the authors describe the design of a nitric oxide-driven nanomotor loaded with the glycolysis inhibitor lanodamin, breaking through the blood-brain barrier and eliciting anti-tumour immune responses in preclinical models of glioblastoma. This article was authored by Huang Chen, Ting Li, Ji Young Liu, and others.