 The study compared the efficacy of pregabalin plus Vibuprofen versus pregabalin alone in reducing postoperative opioid consumption and pain scores in patients undergoing laparoscopic colosistectomy. The results showed that pre-emptive use of pregabalin plus Vibuprofen reduced postoperative opioid consumption, rescue analgesia usage, and pachyste compared to pregabalin alone. This article was offered by Omicorica, Husein Uplar, Imin Turk, and others.