 This study examined the effects of increased positive end expiratory pressure, PEEP, on brain tissue oxygenation, PBTO2, and intracranial pressure, ICP, in acute brain injury patients under mechanical ventilation who were monitored with intracranial pressure and PBTO2 catheters. The study found that increasing PEEP from 6 to 10 CMH2O resulted in a significant increase in PBTO2 from 21 to 23 millimeters of mercury while ICP remained unchanged at 12 mm of mercury. Of the 163 episodes of PEEP increments with concomitant PBTO2 monitoring, 34, 21% were PBTO2 responders, meaning their PBTO2 increased by more than 20% after PEEP increase. A lower baseline PBTO2 value was associated with the probability of being a responder. The study also found that there was a moderate positive correlation between the change in PBTO2, PBTO2, and the change in PEEP, PEEP, in PBTO2 responders, suggesting that increasing PEEP may improve brain oxygenation in these patients. However, the response to PEEP elevations in brain injury patients is highly variable and no baseline variable was able to identify the response in ICP. This article was offered by Eliza Guvia-Bagossian, Joaquin Cantos, Anita Farinella, and others. We are article.tv, links in the description below.