 Abstract, this study aimed to increase the genetic diversity of plasmodium falciparum parasites to accelerate the selection of drug-resistant mutants. To do so, researchers modified the enzyme DNA polymerase, which is responsible for replicating the malaria parasite's genome. By modifying the enzyme, they were able to increase the number of mutations in the parasite population, resulting in faster resistance development against certain drugs. Additionally, the researchers identified a new gene, QRP1, which was found to be associated with resistance to a specific class of drugs. This article was authored by Kritikon Komponson, Theorat Kochakon, Thomas Yo, and others.