 Antimicrobial stewardship programs, ASPS, are essential to reduce the spread of antibiotic-resistant bacteria and improve patient outcomes in both developed and developing countries. In Latin America, however, there is limited evidence of successful implementation of these programs due to lack of resources and knowledge about best practices. To address this issue, it is important to understand the current state of antimicrobial stewardship in the region and identify gaps in knowledge and resources. This paper provides an overview of existing antimicrobial stewardship initiatives in Latin America and identifies key elements necessary for success. This article was authored by Valeria Fabre, Sara E. Cosgrove, Clara Siqueira, and others.