 This review aims to summarize the advantages and pitfalls of available animal models used in studying bone healing in osteoporosis. The proximal tibia osteotomy model is the most popular, but other well characterized models should also be considered. The critical size defect model may be useful for clarifying the regenerative potential of osteoporotic bone and its response to biomaterials regenerative techniques. When selecting an animal model, factors such as bone remodelling, lifespan, age of peak bone mass, economic and ethical implications should be considered. Additionally, the influence of species, sex, age, and strain on outcome measurement should be taken into account. Standardized international guidelines for osteoporotic animal models of bone healing are needed to make future studies meaningful. This article was authored by Elena Calcilari, Nikolaos Donos, and Nikos Mardas.