 This study aimed to evaluate possible causal associations between gut microbiota and psoriasis using two-sample Mendelian randomization, MR, with published large-scale GWAS summary data sets. The results showed that Bacteroidates, Prevotella 9, Bacteroidia, Bacteroidales, Ruminococcusiacea UCG002, Pasterella CE, Blascia, Methanobrevibacter, and Eubacterium Physicotina group are nominal risk or protective factors for psoriasis and orthopathic psoriasis PSA. After false discovery rate correction, E. Physicotina group remains a risk factor for psoriasis. These findings offer promising therapeutic targets for psoriasis clinical management. This article was authored by Chen Yangzong, GNU, Manune Mao, and others.