 Hello everybody. If you were here earlier today, this is the second live we're doing today. I'm super excited about this one with Kashif Khan. Am I staying your name right? You can say it however you want. You're so awesome because I'm horrible at names and spelling. So the funny thing is it's actually Kashif. But I didn't know that until I was like 18 because I got called Kashif growing up by everybody. Wow. And finally one day my mom told me I think I should tell you how your names Oh that's so funny. Okay thanks mom. Oh gosh. Well a little background if you haven't joined us before it's Dr. Jill live and we're on almost 90 episodes. So you can find them all at my YouTube channel on the videos or anywhere you listen to podcasts and iTunes. Always have fun learning from my guest and today will be no different on that. I will introduce Kashif in just a moment. You can also find all of my blogs and resources at jillcarnahan.com. Tons and tons of free resources there for you on mold and environmental toxicity and Lyme disease and all the many illnesses that our patients deal with all free all there. Dr. Jill Health you can find my products and services there as well. So let's dive in and let me introduce my guest today and then super excited about the opportunity for you guys to go deeper into your genetics. Often what I find with patients is you know we'll look at environmental toxicity and infections and all of that. The genes are the foundation and they really really do make a difference in treatment protocols so I do find this incredibly helpful and more and more patients are being empowered to learn about this to ask their doctors about it and this is today going to give you a great resource that you can access on your own and get more information. So let me introduce my guest Kashif Khan chief executive officer and founder of the DNA company where personalized medicine is being pioneered through unique insights into the human genome and what I love about you about what you guys do which we'll talk about today is you make it really relevant and really easy to understand because what I found I've been doing functional medicine 20 years and even as a physician who understands this stuff depending on how you report the data it makes all the difference doesn't it and you guys really really made an effort to report the data in a way that's understandable and that makes actually practical applications so I'm super excited to talk about that. So with the largest study of its kind globally the DNA company has developed a functional approach to genomic interpretation overlaying environment nutrition and lifestyle on the genetic blueprint to create personalized and deterministic health outcomes kind of like what we're just saying. Growing up in Vancouver Canada as an immigrant Kashif developed an industrious entrepreneurial spirit from a young age prior to his tenure at the DNA company he advised a number of high growth startups and a variety of industries including luxury retail technology finance fine arts healthcare tourism and real estate he participated in over three million in revenue in his own retail business prior to launching consulting services to help others thrive as Kashif died in the field of functional genomics as a CEO of the DNA company it was revealed that his own neural wiring was actually genetically designed to be entrepreneurial how cool I want to hear more about that I want to hear about that I have found I have there's a gene they call the empathy gene so that I don't know if you know but there's one that relates we'll get into that very cool however his genes also revealed a particular sensitivity to pollutants I have that too this inspired him to develop custom nutrient supplementation to enhance this poor detoxification pathway and like me to first both to deal with pollutants chemicals and reducing risk of long-term illness this is so relevant because as we spoke right before we got on live here in superior Lewisville we just got over December 30th the largest wildfire disaster in the history of Colorado came through burning over a thousand homes and businesses and so we've been directly affected and what I realized I've known wildfires damaging but it is probably more toxic than mold exposure as far as the amount of plastic chemicals to leave benzene so this is very relevant because what happens in someone like me or you or I we have issues with either production of glutathione or whatever detoxification pathways so we're more susceptible to the environmental impacts and things like wildfires are happening more frequently um so anyway that's a whole other issue but let me enter let me just let you go and I want to hear first how did you get into this sounds like you had some personal experience tell us how you really got I did I was sick and I went through the thing that you said about you know data not being so useful unless it's interpreted properly really data is dumb it's a bunch of information and unless you know what question to ask you're not going to get an insight which is much more important than data right so that was my experience because my previous life I was a PR and marketing firm owner that's what I did I I'm in Toronto Canada right now that's where our firm was run we helped small medium large companies grow and I got sick I was I'm 42 now I was 35 36 at the time eczema psoriasis I had migraines all the time I had acid reflux issue I couldn't eat anything I was depressed at least twice a month so all this stuff was being treated as separate siloed health conditions with a doctor for this and a doctor for this and a pill for this and a cream for this and I just kept going down that rabbit hole and finding more problems that I needed to fix and none of them were being resolved they were all sort of being maintained and you've heard you hear this story so much when somebody stumbles across functional medicine and their whole life changes and they understand root cause and for me how you get to root cause there's different paths for me it was through genetics so I understood that all of this stuff wasn't many different things that I happen to be you know subjected to these were the results of my poor choices and what my genetics led to meaning you talk about detox yeah forget about ability to detoxify there's certain genes that I don't even have there's something called a copy number variation or forget about the variant or snip that we talk about I'm literally missing the GSTT1 gene which is the most important glutathione gene I don't even have it so meanwhile my office was sitting a few floors above a manufacturing company with pollutants and solder and all sorts of stuff coming through the vent all and you wonder why I had migraines and my business partner had no issue he used to drive me home vomiting wow yeah relative this is really interesting I mentioned this one other time but I just found out I've been interviewing my family members for the book I'm writing and my grandmother I just found out this year she's 90 years old back in when she was 15 her father moved her over auto dealership that he had bought and they had the car um auto body shop underneath and so benzene lead and things kind of like what you see in the office and literally it's a liver toxicant her father died of liver cancer her mother died of liver failure her brother died of metastatic cancer like over every single person in her family and she was able to get out because she was the oldest one of the children but same thing and her genetics like mine are it has some impaired detoxification and this is what you said is so important because this is the one thing this was that trigger point for me where I literally took the keys to our marketing company handed it to the staff and said thank you you own it now I literally walked away and said I got to build this thing and what was it is exactly what you just said which I learned first of all when I first looked at genetics it failed me also I didn't get much out of it right it's when I started to look at functional genomics meaning let's first understand how the body works what are the systems and pathways that are actually you know the biochemistry that's going on and then reverse engineer what genes instruct them as per the system as per the map it's not then what a doctor would say well you have a genetic propensity to deliver disease in your cat in your family that's that's what the answer would be it's three out of three so it's in your genes there's no they were not born with a liver disease yeah they were born healthy so they should be able to stay healthy what they are born with genetically was an inability to deal with that glutathione pathway properly for which the end result is too much load on the liver yes which equals liver disease so they weren't born with a propensity to disease they were born to overworked hardware right this particular organ is struggling and struggling and struggling because you're making the wrong choices so now all of a sudden if you understand the systems and you understand the core things that lead to good health hormones detox methylation your anti-inflammatory system your neurochemicals in your brain and how you perceive things for example why I'm entrepreneurial you then know what to focus on and then it doesn't matter what all these spokes of different diseases that come out of the central hub you don't need to have any of them and if you have them stop treating them reverse them because you get to the root cause and that's what was the light bulb for me that all of them my eczema was gone thrice was gone I haven't had a cold or a flu in like four years I used to be in bed three times every winter season for 10 days at a time because I just wasn't healthy right and that's all gone now wow fascinating and so true and again I've used your testing on myself and on patients and it's profound to understand those pieces of the puzzle and and that can be very small little things that we find out that make all the difference in their health right and going back to what you said there about easy to use that was one of the very first things you said I actually learned that so there's a company up here called Rogers which is one of our big telecom like our AT&T right and their chief digital officer was one of our patients and he's he went through we used to do a highly hands-on executive process because we didn't know how to make it available to everybody and that was very expensive because our scientists would have to interpret the DNA figure it out and then build a plan and work with you and he said what you have here can literally flip health care it's on on its head you just need to make it easy to use because that's my number one advice to you as a chief digital officer of a multi billion dollar company make it easy so that's what I then put my full focus on and the number one thing they're making it easy to use is people don't care what their gene results are they care here's what's wrong and here's how to fix it that's it right here's your problem I figured it out tell me that quickly what's really going on and here's what I recommend that will fix it for you the genes might inform that great there's we know there's science to back it up but I don't need to know this snip and this version in 20 000 letters I write it so what we do now is we the same interpretation our scientists were doing when they would read all this raw data our artificial intelligence platform which we built does that interpretation and the report the consumer looks at or the clinician because it's also hard for clinicians to interpret speaks to the condition I don't need to know I have GSTT1 null which I have I need to know you're at higher risk for liver disease you're at higher risk for mold sensitivity you're at higher risk for chemical sensitivity oh by the way here's why yes now I can take action now I can apply it and that's that's what we did and I want to speak as a clinician too because I have used dozens of genetic companies some of them better than others and big thing for us is sometimes we'll get reports like and if we were print them they're electronic an inch thick and there's no way to go through that with a patient in a normal office visit so even more so your doctor if you do get these results especially I know genetics really well so even complex tests I can usually find the important stuff quickly for patients but many many doctors this is new to them so if you bring in a report that you've done you're overwhelming them sadly this shouldn't be overwhelmed right but that's the way we are because there's a lot going on and so you bring this huge report and it's completely overwhelming and they don't know how to help you this is what I love about your company is you're going directly to the patient you're powering them and granted they can do changes on their own but if they're working with a great functional or integrative doctor this can enhance their visits too and it helps the doctor like me to make easy decisions on what next to do exactly it's fast and easy to the point and we speak to the condition and it's actionable it's not when people think about genetics they think oh I'm going to find out if I have an 80% chance of Alzheimer's right what does that give you other than anxiety for the next three years right that does not do anything for you other than like it's a tease towards a problem what you actually need to know why does Alzheimer's happen correct correct right what causes it why does health Canada now call a lot of Alzheimer's type 3 diabetes correct very quietly your doctor doesn't probably doesn't even know that but they've refrained they just they have to it was so obvious so now it's not about a gene for which we clinically tested 80% of people that had this gene very involved Alzheimer's but you still can't tell me why yeah the why is the most important part once we get into the why then you are looking at actually very different genes that's like you said liver versus detox liver is the outcome right detox is the the root so that's what we do it's not about hey you got 80% chance of all Alzheimer's is here's the choices you need to make for you to avoid it here's the choices that you need to make for you to 100% get it and now the choice is yours which path you take yeah so love that because like you I have a lot of detox genetics I grew up on a farm with adresine and chemicals and things I got breast cancer at 25 years old and so I'm like and I had the eczema and all those psoriasis all the same and all those things are just evidence of a poor detox pathway once I knew the underlying cause I could go to nutrients and diet and lifestyle and again what I love about your reports is you guys have taken the science and put together pretty easy to implement interventions depending on the genetics maybe let's talk about a few that like maybe give an example of a couple of genes you might see and then what an intervention would be we've already talked about glutathione and I both have those and go ahead well you know you mentioned breast cancer and I think that's important to talk about because first of all it's one of those big scary things that every woman is worried about and I would say of all the research we've done so you mentioned the beginning that we've done this large study where we've sat in front of thousands of people we've actually met all our patients documented everything and I would say the biggest area that needs the most change is female hormone health that's the area where the experience sucks so bad you know that delta value between what you're told and what's actually possible it's all this gray area it's very black and white if you understand it so if we use as an example most women have heard of the brachy gene and it's a scary four letter word and if you ask a woman do you want the brachy gene she will say no because she doesn't know what it means and even if you ask the doctor should I it's not about a gene it's about one version of it but then you ask the question what does that gene do so if you have a particular variant it's a it's a tumor suppressor it's a repairman or repair woman so it goes out and fixes problems it doesn't cause cancer right but if you have cancer if you have a tumor it's meant to go to work and suppress it if you have a not so good repair tool it's not going to do such a good job repairing so the clinical answer is oh bad brachy you don't repair well go get a double vasectomy that's prevention yeah right or you can ask why did the cancer happen in the first place I have a repairman that can't repair how about if I don't break it correct okay I love that you're saying this because here's the question I get all the time 25 year old I was the youngest diagnosed in 2001 in my medical school in Loyola in Chicago which is a major medical center so at that time 25 was unheard of to get breast every single person oh do you have the BRCA gene no I don't and 80 90 percent of us as young women who you know these these odd balls that are one in a million chances of us getting at that age we don't have that gene because that's not the root cause it's more of these bigger like you said so it's very relevant because a lot of people think that gene is the indicator it's it's one thing but it's after the fact like you said the repair mechanism and it's not like for me it was all about detox and chemicals and form regulators so very relevant especially to my story so I'll give you an actual example that's probably related to your story story and and like you said BRCA is the thing that goes and fixes it doesn't cause it so and by the way to answer your question about you know 25 that was unheard of well it's also because the level of chemicals when you were 25 was also unheard of yes one generation ago it didn't look like that anybody can go google chemical usage of the United States over time historical and they will see a chart that looks like this right and we are all swimming in toxic soup and literally that's the elephant in the room I say it every day the toxic load is just exponentially increasing and 20 years ago since my diagnosis there's 16 there's 23 there's a lot of women younger than me that's actually way more common in the last decade yep so now let's dive into the why the most important part and most women I mean you were exposed to an extreme load but most women experience breast breast cancer in and around the menopause age but it's typically when it happens for the most part not everybody but for the most part so now we're getting to the why so you when you look at the hormone cascade and by the way it's the same for men or women women do a monthly men do a daily what do you do progesterone turns into testosterone turns into estrogen which then turns into an estrogen metabolite and then you get rid of it so we have to ask three questions what is your dominance what is your hormone profile look like are you more androgenized more testosterone are you more estrogenized there's a lot more estrogen or are you somewhere in the middle right that's it's possible there's different variations based on your genes now that we've identified that and suppose as an example a woman is hormone her dominance is estrogen so she's highly estrogen dominant so that woman would if you put kim kardashian and kendall's gender together it's kim kardashian right she's gonna have the big curves the beautiful hair beautiful skin but she's gonna have a whole other bunch of issues that come with it kendall thin supermodel but she's probably gonna have fertility issues acne hair problems etc so step one estrogen dominance step two before you clear that estrogen in your monthly cycle you convert it into a metabolite two four or sixteen hydroxy estrogen two is great you want that it's clean healthy four and sixteen are highly toxic 16 being more toxic than four so now suppose you're estrogen dominant and you're producing 16 hydroxy estrogen then you have to third step see how do you clear and it comes back to the same detox genes along with something called comp another clearance enzyme right how well do i get rid of this toxic stuff that i make every month so now someone's estrogen dominant estrogen toxic doesn't clear well they're still not sick correct right they're still not born with a problem and i want to really quick start to interrupt you but the hormones like estrogen are treated like drugs by our liver so people are like oh well that's something i'm making that's okay yes no if your liver's not working if your detox is not working these are just like extra drugs to your system because they your body has detoxified so even though in your body makes if you don't have detox working it it's like a drug to your system yeah it's like you're plugging the exit route and everything's just getting clogged up with the exit it's gonna over time reach that threshold which is why does why does it take and tell that menopause age right why does it take that long so there's a couple things that happen you no longer have a menstrual cycle so that okay i don't clear well my glutathione pathways my detox pathways aren't that good but at least i had a menstrual cycle where i was getting rid of most most of it now i don't do that anymore 85 percent of north american women will be on the birth control pill for an elongated period it's part of the culture yeah so that's more estrogen more fuel to the fire more metabolite more that needs to be clear when you no longer have that cycle when you're menopausal and you may also be on a hormone therapy because your doctor told you to right what happens is your body doesn't clear because you don't have a cycle your body starts to store it in fatty tissue because it wants to keep it away from the organs wants to keep you safe where do you have fatty tissue and your hips and your breasts right and what's in the breast that was never designed to deal with that level of toxic insult all that sensitive all the receptors all the hormone receptors yeah you were not this this was not designed to deal with that you were meant to not have 15 years of birth control pill your body never understood that that's what you were going to do to yourself you weren't meant to have chemicals in every single which way you go that are endocrine disruptors and mimic hormones that cause even more problems you weren't meant to be using a teflon plant pan that is literally an endocrine disruptor all these things that are a load that take you from well I might have a bad profile but I'm still not sick well here's the load that's why we say environment nutrition lifestyle what did you do with the cards you were dealt and for some women that women that not their fault they just didn't know because we're not taught this did the wrong things increase that estrogen load more metabolite more inflammation faster breast cancer then after all that BRCA should go to work and try and help you yes love love love this because again what you're cleaning that is what women don't realize a lot of them maybe those listening here to know because I've talked about a lot but you mentioned endocrine disruptors they are everywhere the first thing I did the year after my cancer was why did this happen I went and looked at chemicals and I looked at bath and beauty products I looked at cleaning products I looked at all the things in my home and that I put on my body and many of them were endocrine disruptors and then on the farm I grew up with toxic organophosphates atrazine et cetera and many many herbicides pesticides load in my well water you know you can see it happening so there's a lot of things in your environment that are contributing to an estrogen like sensation in your body is basically like those chemicals look like estrogen to your cells so if you have you have this load of excess estrogen in your body or not you dox find that you're making yourself and then the chemicals you put on your face phthalates parabens organophosphates on your food if you're not eating organic and then pesticides and herbicides these things all add to that load and that's what we're talking about yeah you have to understand that our DNA is 250,000 years old meaning that we that's what we inherited it started in around that time that people started to look the way we look today so this blip in time this two generations maybe three of heavy chemical usage heavy like all the stuff we're talking about here we're talking about like 100 150 years versus 250,000 years of what we inherited that that we were designed to do that so imagine how impactful it is on the system that was designed to do what those people did for 250,000 years until the last few hundred years there was kind of industrialization industrialization there's small pollution etc etc it's such a new blip versus what we're designed to do that we're just can't handle it we're not designed for now this is this leads me to another thing i'm going to focus again on women because i think it's so impactful and so important 66 of women who have a cardiovascular issue will die on that first instance it's much more impactful for women yeah yes this much more impactful no previous warning sign no pain no nothing heart attack boom on that first heart attack 66 it's much lower for men because we don't also have that estrogen toxicity load which is also causing that inflammatory issue which leads to that cardiovascular disease so why do you have that cardiovascular disease again i'm brown right i'm a middle eastern mutt i have a little bit of pakistani indian turkish of ghani like there's a little bit of everything in me so i'm told that genetically i have a bad heart that i should expect to get diabetes and cardiovascular disease except i guess what my dad had all of those things and he died when i was 17 my grandmother had them my uncles had them right it's not because they have bad hearts it's because their hearts were designed for what their ancestors did who never had cardiovascular diseases until they moved here yeah right and it does not diet the standard making diet plus the chemicals plus all these things in our body like exactly so now if you inherit the genetic legacy of people that did not have cardiovascular diseases what did you inherit and this goes to speak to women and why is there that compound effect of hormones plus bad cardiovascular genetics equals a problem so 9p21 determines how robust the endothelial lining is so heart disease typically doesn't happen in the heart it's usually in the arteries right calcification blockage cholesterol and stuff that then leads to the heart now getting a blood heart attack right so the inner lining of that artery is called the endothelial there's different quality versions you can have a stainless steel endothelial and you see grandma smoking when she's 95 never got sick she probably has that right then you also see somewhat normal version which actually isn't what you're supposed to have you should have the stainless steel version and then there's a paper thin prone to inflammation if you test both south asian people who are told they have bad hearts there's nothing wrong with the heart they typically have bad endothelial linings poor quality because they just didn't need a good quality because there was nothing causing inflammation right now they also typically have poor detox pathways like myself because didn't need it yeah everything was organic and pure there was nothing to detox so didn't need it they also have poor methylation or anti-inflammatory pathways because if there's no detox or if there's no toxins there's no inflammation if there's no inflammation what anti-inflammatory mechanism do you need what are you fighting right so that whole methylation pathway is usually suboptimal so that sort of perfect storm of then all of a sudden changing the environment nutrition and lifestyle and having the inflammatory loads and then cause damage literally abrasions to this endothelial then you start to get inflammation here for which you don't have the anti-inflammatory system to fight it yeah so what does your body do it actually deploys cholesterol as a hormone to reduce the inflammation and when cholesterol meets toxicity it hardens it gets deposited then you get the beginnings of cholesterolemia now take that and compound it with a woman who has estrogen toxicity dominance and she's getting it from two fronts which is why when you finally cross that threshold where you have the heart attack it's hard to recover because it's so much more powerful and impactful for a woman right so you got to think about the heart disease is not the disease the heart disease is for 50 years you did the wrong thing correct correct you abuse this organ like crazy and now it gave up yeah exactly I love this because it's so relative to women I was just thinking I didn't plan on doing this but I literally have if we take just two minutes I could share what my results were I'm gonna be real horrible and you obviously know what they look like and you can show um now the reports might have up been updated since I originally got these but they're still beautiful and I think are very relevant because what I've noticed in the last couple years the way your reporting is just continuing to so forgive me if this is an older version I'm gonna share because again I think it'd be okay you can see my screen so yeah so yeah let's talk about this these are our clinical reports so this is not what a consumer gets and this is very specific reason why this requires interpretation yes yes right so uh what does this map mean this is your hormonal cascade so as we said on the far left you start with progesterone in the middle you convert that to progesterone sorry testosterone and then on the bottom you drop down to estrogen it's it seems that simple but because of these red and green and you know orange lights there's different speeds at which these genes are up and I just want to say that was brilliant again this has been a couple years now your reports are even better and they're much more consumer friendly but to me this was so brilliant the red green yellow lights because you can just glance at this and see oh those pathways are kind of like red light right so easy yeah so what do we know about you first step your hormone pool is very low to begin with right you're not converting progesterones into testosterone but the good news is if you go up to the upper left you're not clearing those androgens those testosterone you use them for a while which is why even if you look at yourself you're more antigenized you have the more chiseled which you know women want the beautiful elongated face or the chiseled body right so that comes from holding on to these this testosterone for a while you don't then go across to the right and produce DHT which is why I saw hair lots of hair this is why exactly so women that are suffering from acne or hair loss or PCOS polycystin ovarian syndrome this is all rooted in this DHT and of the DHT you produce there's a yellow light which on the top right which means you're getting rid of it at sort of a medium fast speed so it's really not a concern because this is actually really easy with the cancer what you mentioned before so I'll just explain cytochromes are our liver space one ability to detoxify things so I love the way this is set up because these are like we know 4aOH in the middle here's one of those DNA damaging hormone from estrogen and you can clearly see you can explain there what's happening yeah go down another page this is the sample then your results are I think on the next there you go so you red light all the way across what does that mean you're yeah your metabolism your conversion into the toxic stuff is very slow which is good news right but for what I remember your detox pathways aren't the best if you go down a couple yeah so this is why you have to look at things functionally that sample and then this is mine yeah here we go this here exactly yeah so now and this is why genetics isn't this gene means this yeah imagine if I only told you about one gene DHT you're at less risk of toxic testosterone okay but what if I don't clear it well yeah right what if I also produce estrogen metabolites you have to look at the full cascade which means biochemistry first what does the body actually do and then what genes instruct each step so now what we do know is of the toxic metabolites you do produce actually in the GSTT family you are clearing quite well it's your SOD2 or your oxidative stress genes that aren't doing the best and your COMPT also wasn't doing the best so that means you would probably want support here even though you don't produce so much of the four hydroxy you still want to do something to get ahead of of the little that you have let's clear it let's supplement and let's do some things to get rid of it right and where do you focus SOD2 is a gene that determines how well you deal with clearance at the mitochondrial level so whereas GSTT1 is like the police force in the blood it's going around binding onto toxin sending it to the liver to metabolize glutathione right GSTP1 is sort of that first line of defense of the lungs I breathe in mold fumes whatever I have these soldiers that are helping here this is literally right at the cell so SOD2 in the middle here is your cells take an energy I'm sorry they take in oxygen and nutrition to create energy right that's what they're all doing the same thing in that process they also create oxidant so oxygen becomes oxidant which is toxic yes and you don't and you don't want so some people don't deal with that including yourself so well yeah so if you get into oxidative stress you're going to struggle more than another person which means if you were to become a marathon runner you're likely to develop more wrinkles your hair is going to turn gray faster this is oxidative stress which is our like root cause of the damage of DNA and for me it's interesting just a little side note the hydrogen tabs and hydrogen breathing machine basically neutralizes this and I found that right in changer for me right exactly so now you know where to focus yeah okay so thanks for letting me go there but I thought I'm able to see how amazing this is the information and how and again you've got way better reports than even those now yeah so it's so clear and easy to see the red light the green light and now again you've got some interpretation a lot more information maybe you can even tell us what you've done since those sure so what what we did was we went through 7,000 people one by one by one like internally as clinical patients and we learned as I said a while ago people want to know what's wrong how I fix it you know it's not don't give me my encyclopedia of genes I don't need a full genome sequence 22,000 genes tell me what I need to work on tell me the five genes I need to work on right and we broke that down into six things which is if you go through these six it kind of resolves most human optimization I want to prevent the disease I want to slow aging down and I want to be at my optimal performance level that's kind of what everybody wants and if you go through these six things you get that and one cardiovascular we talked about that so understanding the biggest killer in the world yeah which why it really happens why does diabetes really happen what do you do about it and then second is hormones but in the hormone report that the consumer gets we go more into the sort of applicable stuff like fitness body type how do I if I want to put on muscle from my report you might say avoid smoking and do some moderate cardiovascular exercise maybe try some sulfora veins to help the estrogen so you would give real practical recommendations based on that which is one specific recommendations yeah that are based on the genome then we get into diet nutrition and there's a lot of genetic tests out there that do nutrigenomics or tell you what to eat we do it more at the sort of biological level meaning the macros are you a fat metabolizer are you insulin resistant are you a starch metabolizer how do you handle vitamin D you know vitamin D of the 22,000 genes in your body 2000 require vitamin D to function so literally 10 percent of your body's biochemistry is dependent on this one hormone is what it actually is yeah in order to function properly right so now imagine if vitamin D in your blood to go get a blood test is a step one of three and even if you have enough in your blood it doesn't mean that you're doing genetic step two which is transporting it to the cell where it's actually used you could have plenty in the blood but you never actually transported so you're not using it you might not do step three which is binding it at the cell and actually utilizing it we have plenty of people that test fine you know at the doctors but they have mood issues every winter so it's like vdr that's the receptor right vdr exactly that one for sure so that's many other receptor level you need a higher dose to get to the the the message exactly yeah the regular dose isn't enough for you and if you're not a good transporter you need multiple doses yeah right because you need to transport 10 but you only have two seats in the car yeah wow right so then all of a sudden you need to do it multiple times so understanding that one thing can completely change somebody's health because vitamin D is so important so anyways diet nutrition then we look at sleep because it's so important in terms of recovery health and and this was something that we never even intended to do it just every time we help somebody got healthy sleep was a big part of it and so we've understood sleep isn't about hey i can't sleep no it's i can't fall asleep yeah or i can't stay asleep i fall asleep just fine but i wake up at three or four am and i just can't get back to sleep or i sleep through the night but i wake up feeling like crap i did good good quality sleep genetically these are three different things right then we look at mood and behavior so the neurochemicals of your brain which is actually the biggest report it's double the size of everything else and if i had your dna which i do if i had never spoken to you i don't need to to understand your personality do you procrastinate are you irritable you know are you going to how deep are we going to dive in this conversation you know how curious are you going to be are you actually wired to be a clinician or not that's all pre-written in your dna because we understand how your genetics instruct neurochemicals but we also understand what those neuro neurochemicals equal in terms of traits in terms of mood and behavior so and i'll get into that using my example you asked about entrepreneurialism so and then the last thing is information detox and immunity so that core cellular health how healthy are yourselves and why and what to do about it so going back to mood and behavior so myself uh let's take the dopamine pathway most people are familiar with that so dopamine is your ability to feel reward or pleasure it does two things so there's a gene called drd2 which determines how dense your receptors are so your ability to actually bind that dopamine and use it and feel it i have a very sparse poor quality receptors so i don't bind much there's a gene called mao which then is responsible to break the dopamine up so once it's bound you need to get back to normal eventually so mao breaks it up there's another gene called comp the same one that we saw that clears the hormones also clears neurochemicals so i have the slim to none dopamine receptors so i don't feel much might have the fastest possible mao and the fastest possible clumped so i feel a way down here and it lasts like that wow so i have three potential outcomes i don't ever get the pleasure or reward and i get depressed which i was as i said when i was working right yeah or i go down the pleasure route and i become addicted yeah right because i i found the thing that gives me that dopamine hit that i don't get to experience and it's so satisfying that i have to keep doing i keep doing it or i go down the reward route and i achieve yep which is where i unintentionally landed because of i needed to because i was taking care of my mother my mother and my sister because my father passed away right so i literally had to take care of the family so i started working out yeah right so i unintentionally went down this reward route and whatever i did yesterday just wasn't good enough that business i'm doing i can do better i met this guy he's not as smart as me i can do better than him and then reward reward reward reward and that's where what i why i walk away from a pr marketing company to start a biotech company that i have no business doing right right and and so that one pathway now you can layer other things on top of that serotonin serotonin is your mood regulator what if you don't do such a good job there you know what if like me i have the somewhat dysregulated ability to cope and deal with serotonin so for me all the details in the stimuli are slightly exaggerated yeah so not only am i perceiving or sorry pursuing reward but i'm perceiving things a little more than they are meant to be perceived right in the meeting when the clock is ticking when the food is being chewed whatever's going on it bothers me and that could present as add for some people right like destructible yeah you're very indestructible right distract and it's not that i'm distractible i'm motivatable that's not even a word i just made it up love it love it i get drawn to things right and i just have to focus now that i know that other things that will keep me drawn towards my goal whatever i'm trying to do so every stimuli whether positive or various okay it looks like i'm bipolar i can be bothered by something and irritated but very easily brought back up to laughing and joking if i'm stimulated in that direction yeah right i just need to be pulled so i just gotta be careful what i'm being pulled but guess what that same serotonin going back to sleep right the thing we talked about why is it that some people fall asleep and this is the biggest sleep problem actually that we found it's not that people can't fall or they can't sleep it's that they wake up in the middle of the night yeah and why is it melatonin and circadian rhythm are the two things that kind of put you to sleep your internal clock and people do okay there and there's enough melatonin supplements you can take that help you what people don't understand is melatonin is your go to sleep chemical serotonin is your wake-up chemical right so you start making serotonin at that first light that first stimuli what if that first stimuli is your spouse pulling the blanket or it's getting too hot after three hours of sleeping or there's light leakage through the drapes and you wake up because i think a lot of your listeners will know sleep isn't eight hours straight it's cycles right you're in and out in and out some people can do that some people wake up and they can't get back to sleep because their body thought they're finished yeah because they're serotonin and this was me i used to there was days where i'd wake up at 3 a.m and start working i wasn't okay i was still tired i just couldn't sleep right now i know why so you're saying was it not broken down or was it uh excessively reproduced so i have a slightly shorter uh receptors so i don't bind enough so that that's response to stimuli is exaggerated yeah okay that makes it so so little things would wake you up and you'd be cortisol serotonin everything the way okay that makes every that's going and then your body thinks it's time to get up yeah yeah right and then you're in serotonin mode the serotonin starts pumping which is not meant to do until you're ready to get up right so that's so these these neurochemicals once we started and this is why we did what we did of meeting 7 000 people because it wasn't until we anecdotally asked them tell us about this tell us about that we were able to collect all these insights right data like we said is dumb your serotonin isn't the best what does that mean yeah we need to meet patients to find out what it means so i'm curious and again we i don't have my results right in front of me but just that from what you've said i love dopamine i think i produced a lot of it i actually think i don't break it down but i also i seek out adventurous kinds of things is that a pattern you see with genetics with the dopamine so what we see typically and this may have to do with the audience that comes to us but we typically see one extreme or the other we don't see much in the middle so what do we see me the addict the reward seeker right then we also see the maximum dopamine receptors that person is the binger ah meaning that because it's so easy for them to experience pleasure and reward they really aren't bothered to pursue it oh yeah right so you go sit in a meeting with them okay they're going to talk about 10 things you as a group and next week comes by and they've done two of them yeah and they ate they never even said because they just don't care yeah right but the two that they did they will do better than anybody interesting because that's what caused them to experience that reward and when you have high dopamine receptors high density yeah you stay in the reward you get lost and you do binge because it's so good to be in that and that this week when it's work play whatever it is yeah the person that can watch eight Netflix episodes until 4am and just can't turn it off yeah that's the binger right okay i'm just more like you because i need to seek those like motorcycle riding and rock climbs i love those little because it but it probably goes away pretty quickly the little hits and you and you need it structured it's not the binger just needs it when it happens the addict needs it regularly yeah okay right if i don't get to the gym i am extremely frustrated yes here's a good same thing i was addicted to exercise it was like right yeah yeah you're addicted but the the binger is like i don't need to go but when i go i'm gonna go like i'm gonna stay there for two hours from wow interesting okay this is fascinating and again i've known a lot about genetics that i'm learning some new things here too and now i'm at yeah go ahead so all the last thing i was gonna say about that is imagine now knowing this about yourself and how personalized your protocols can be meaning that one go do this right go do whatever you have to do you have to first understand how do you even perceive what does go do this mean yeah right how are you actually going to handle those instructions of take this medicine do this exercise go train your abs whatever it is right how do you actually put that into practice where you stick to it and you don't fail that starts with understanding how you think fascinating and again so relevant for people to to be able to access this so what's the different you have uh i don't know six or more different um types of tests that they can be ordered tell us about the actual yeah so categories in the one test we provide all of what i've spoken of so the six sleep cardiovascular etc we just believe that this is what everybody yeah needs right uh from there if we want to get clinical like if somebody says well you know i i have fibromyalgia or like mold sensitivity and they want to dive deeper and fix a problem we have coaches that are trained on genetics that can build a program with you and they can work with you for weeks on end uh in fact we even have an executive program which is where we started we first started off as super high ticket because that was the only way to do what we did it was all hands on with expensive scientists right so um that still exists some people want that full like take my genome and just renovate me just do everything right yeah so that still exists but for the most part if you have the reports in front of you it's actionable and it's easy so you know where to focus you know what to do about it but if there's an actual problem you're trying to solve i need to lose 10 pounds i need to get rid of my fibromyalgia i need i have a fertility issue that's where i would highly recommend getting on board with a coach to implement the behavior changes because that's the biggest challenge anything for people is to actually stick to what's being told and not have the reports in a drawer somewhere and then go on to the next test right yeah fascinating oh my gosh this is great and again i knew a lot about your company but i learned some things today i like i said i love the accessibility i love the legibility the ability for people to take what they're looking at and implement it and then the fact that you have coaches and you've really done an amazing job in developing the company to make it applicable um if you're listening here um on facebook or on youtube or on uh wherever you're listening well make sure and provide a link if you want to order you can directly contact the company i'm gonna put a link there for that um what else is on the horizon what's the anything else coming out or that you're working on for future yeah we i mean we are a research company at heart like that's what we truly do we know that we have to allow people access we built reports we built the artificial intelligence program people can get into it but we never stop researching and learning and i would say the two areas where my focus is sort of the most what are the next steps it's female hormone health like i said because i think it's giving a report is not enough i literally think we need a second medical system that works alongside of this one that was built on studying men um you know 70 percent of all timers patients are women yet 70 percent of the research dollars is spent on men yeah how does that make any sense that's why 70 percent of women aren't being helped right so that's the next thing we're doing is building that female hormone business it's not just about a report but let us clinically help you as literally a telemedicine clinic the second thing we're doing is we're saying anytime you're talking about prevention the best thing you could do is start early if i can give you here's your instruction manual i've decoded your genetics here's what all your instructions are telling all yourselves to do by the way i can see this in 10 years this in 20 years and this this in six years wouldn't you want that information when you're like five years old yeah right so the second thing we've done or we're working on i should say what's next is we're reinterpreting all of what we know for kids oh wow that's because and why i because me myself the place i use this most in our house is for my kids yeah right the place that how do i teach this kid versus this kid how do i discipline this kid versus this kid why is this kid when i come and yell and say why did this happen one kid does it again five minutes later and the next kid can't look at me for two days right right right that goes back to the empathy genes you're talking about and the ability to literally imprint negative stimuli or PTSD or trauma some people literally will burn that thing into them and some people it's as if it didn't even happen wow that's my childhood yeah so imagine knowing that about your kids and everything else body development should they be a linebacker should they be a ballerina you know all that focused stuff what does my kid actually need to me that's the biggest passion project we have because i've seen the impact in our own yeah so and that's what we're doing but you know to get the reports like where do we start uh i would even suggest instead of going to our website people should go to the the landing page that we have with you why because they'll get extra stuff meaning if you go to our website which is where people go by the way our website is where the general world goes to to buy um we i know that a lot of your audience is focused on sort of environmental health issues mold issues etc so we actually built a guide for mold and environmental health uh which we're going to tack on to the report so it's not a product you can buy it doesn't exist on our website it's just going to help people navigate the report for that specific issue and it's the one area where even if you don't think you have an environmental health problem you're probably exactly and you and i were perfect uh you know examples of that i'm going to give you that out like said this link will be there but it's easy to actually tell you so write this down go there get the reports it's just dr jill no dots or commas or anything dr jlll dot dna dot clinic and then um backslash so just dr jill dot dna dot clinic and would love for you to go there you can order it directly and and get your reports and that and thank you for doing one of the reasons no problem loving collaborating because you guys are so cutting edge at giving tools that we can empower our patients and our listeners yep that's awesome and the reason I'm urging people to go through that link is because we want to know who actually wants that extra document because otherwise it's not a thing that you can buy or it's not for sale but anyone that comes through there will know that that's why you came so we'll give you that extra sort of guidebook yeah and thank you like I said because you empower me to help more people and help patients and this is something you can order you don't need me to order you don't need to see me in the clinic you can actually do something about your own health get the report yourself and start working on that and again you guys have coaches so if you do want some help the dna company will also support you in those other things that you potentially need we're here to support whatever people need and everybody needs a little different from just curiosity to I'm already you know you could be already optimized and just trying to find that next thing to work on to hey I have a clinical representation of something I just need some more advice beyond what my doctor is saying all of the above awesome well thank you thank you for your time today for the great information we will obviously be sharing these links for everybody and thanks again for your time no it's a pleasure awesome talking to you every time