 Sikritin, Sikritin is a hormone that regulates water-homial stasis throughout the body and influences the environment of the duo-denome by regulating secretions in the stomach, pancreas, and liver. It is a peptide hormone produced in the S-cells of the duo-denome, which are located in the intestinal glands. In humans, the secretin peptide is encoded by the S-cellate gene. Sikritin helps regulate the pH of the duo-denome by inhibiting the secretion of gastric acid from the parietal cells of the stomach and stimulating the production of bicarbonate from the ductal cells of the pancreas. It also stimulates bile production by the liver. The bile emulsifies dietary fats in the duo-denome so that pancreatic lipase can act upon them. Meanwhile, in concert with Sikritin's actions, the other main hormones simultaneously issued by the duo-denome, cholecystoconin, is stimulating the gallbladder to contract, delivering its stored bile for the same reason. Crocycretin is a precursor to Sikritin, which is present in digestion. Sikritin is stored in this unusable form, and is activated by gastric acid in the lower intestine to neutralize the pH and ensure no damage is done to the small intestine by the aforementioned acid. In 2007, Sikritin was discovered to play a role in osmoregulation by acting on the hypothalamus, pituitary gland, and kidney.