 Neosomes are a type of liposome-based drug delivery system composed of non-ionic surfactants and hygrophilic solvents. They have been shown to be more stable than other lipid-based formulations, making them suitable for long-term drug delivery. Neosomes can be prepared using a variety of techniques, with the most common being the reverse phase evaporation technique. Various factors affect the stability of neosomes, including the composition of the lipid mixture, the temperature at which the lipid is hydrated, and the critical packing parameter. Neosomes can be used to deliver drugs via oral, parenteral, topical, and pulmonary roots, and have been found to be effective in treating a wide range of diseases. This article was authored by Ghanu P. Kumar and Pagakarajwarao.