 Despite the anticipation of effective COVID-19 vaccines, vaccine hesitancy is widespread worldwide with declining acceptance observed among certain demographics and socioeconomic groups. Factors influencing vaccine receptivity include perceived risk, concerns over safety and effectiveness, doctor recommendations, and inoculation history. Unique factors related to COVID-19 include political party orientation, doubts about expedited development slash approval process, and perceived political interference. Survey wording and answer options can also influence responses. To achieve herd immunity, communication campaigns are needed to restore trust in health authorities and focus on transparency. This article was authored by Cheryl Lin, PQEI-2, and Leslie M. Beech.