 Cevofluorine is a commonly used inhaled anesthetic with a favorable recovery profile. However, the exact mechanism behind this anesthetic action is still unknown. In this study, researchers found that Cevofluorine activates a specific group of neurons in the brain called UCN1-plus-slashcart-plus cells. These cells are also responsible for regulating sleep and when stimulated by Cevofluorine, they release a chemical messenger that causes drowsiness. Additionally, these cells contain a receptor called GHSR, which is necessary for the drug to have its anesthetic effects. When this receptor was blocked, the drug's ability to induce sleep was reduced, suggesting that it may be possible to develop drugs that target this receptor to reduce the side effects of Cevofluorine. This article was authored by Ting Ting Yi, Na Wang, Jing Huang, and others.