 Immune inflammatory rheumatic diseases are common, severe chronic inflammatory conditions that can be used to study the underlying mechanisms of pathogenesis and approach to pharmacotherapy of other diseases associated with autoimmunity and or auto inflammation. These diseases are characterized by uncontrolled inflammation leading to hypercoagulation, which is thought to be a universal pathogenetic mechanism of organ involvement. Inflammation and hypercoagulation are also present in COVID-19 and atherosclerosis, suggesting that thrombo-inflammation may be a key factor in many diseases. Russian rheumatologists have made significant contributions to understanding the overlap between thrombosis and inflammation in systemic lupus erythematosus and antiphospholipid syndrome, which has been useful in treating patients during the COVID-19 pandemic. Additionally, this research could lead to new treatments for both diseases. This article was authored by Yevgeny El-Nazanov, Tatyana Amryshetnyak, Sergey K. Solovyev and others. We are article.tv, links in the description below.