 This study found that youth diagnosed with MISc during the COVID-19 pandemic exhibited a more severe phenotype than those diagnosed earlier on. The authors identified several key differences between the two groups, including higher peak ferritin and anti-probenp levels, increased prevalence of liver enzyme abnormalities, high pulbuminemia, and thrombocytopenia. Additionally, the authors noted that patients in the later stages of the pandemic had a greater need for intensive care and treatment with biological agents. This article was authored by Thomas Rensson, Nils D. Falkett, Kimberly Amador, and others.