 Group 2 and 8 lymphoid cells, ILC2S, have recently gained attention due to their role in the pathogenesis of skin diseases. Research suggests that these cells play a key role in the progression of certain skin diseases, such as psoriasis and atopic dermatitis, as well as in the severity and prognosis of the disease. Additionally, ILC2S may be involved in the development of melanomas, suggesting a possible therapeutic approach for treating this form of cancer. This article was authored by Francesco Borgia, Federica Lipomi, Clara Alessandrello, and others.