 Baker's Yeast in Cronus Disease Can it kill you? Well, that's an inflammatory title, no pun intended. Cronus disease is an inflammatory bowel disease. Mike Baker's yeast, which is the same yeast as Brewer's yeast, which is the same yeast as nutritional yeast, play a role in Cronus disease. It all started with this study published in 1988, showing that people with Cronus disease tend to have more antibodies to yeast than people without Cronus disease. Antibodies are like homing devices our immune system makes to attack foreign invaders. That's one part of our immune system. Another is cell-mediated immunity, where our white blood cells attack invaders directly. And the same hypersensitive reaction to yeast was found in the white blood cells of Cronus disease patients as well. If you draw blood from healthy people, even bakers who are around yeast all the time and you expose their peripheral blood leukocytes, their immune system white blood cells to yeast, nothing happens. I just kind of ignore it, because it's typically harmless. But do the same thing with Cronus disease patients and their white blood cells go crazy. Now when I say typically harmless, if you have cancer or AIDS or are immunocompromised, you could potentially get infected from like homebrewed beer or probiotic yeast supplements. But they don't think the yeast is actually infecting Cronus patients. People with Cronus may just be hypersensitive to exposure to the inactive dead yeast in typical food products, which may help explain why when you rest their bowels, when you make Cronus patients fast, they get better. In fact, that's why we add yeast extracts and proteins to vaccines as an adjuvant, an irritant like aluminum, to make the vaccines work better by heightening the immune response. But might that be raising the risk of autoimmune disease, increasing our immune response a little too much, especially in people who may be genetically susceptible, like with Crohn's. And the greater the anti-yeast response, the more severe the disease in both children and maybe adults, too. So maybe we should try a yeast-free diet for Crohn's patients and see if they get better. But wait a second, just because anti-yeast antibodies are associated with Crohn's disease doesn't mean the reaction to yeast is causing the Crohn's disease. Maybe the Crohn's disease is causing the reaction to yeast. What? Think about it. Crohn's causes an inflamed leaky gut, so maybe the Crohn's came first, allowing yeast particles to leak into the bloodstream resulting in the anti-yeast reaction. So instead of the yeast reaction triggering the Crohn's, maybe the Crohn's just triggers the yeast reaction. Another thing antibodies are actually triggering inflammatory bowel disease or are only consequences of gut inflammation remained elusive. So how could we test it? Well, if anti-yeast antibodies are just a consequence of food particles leaking through the gut, Crohn's patients should have antibodies to all sorts of common foods. But no, higher anti-yeast antibodies in Crohn's disease compared to controls, but no greater reaction in Crohn's patients to milk, wheat, or egg proteins, which would presumably all leak through, too. Or you can look at it the other way. Instead of other foods, what about other inflammatory bowel disorders? Ulcerative colitis or acute gastroenteritis? There you could get inflamed and leaky, too, yet no increased yeast reaction. So there does appear to be something unique about the yeast-Crohn's relationship. But maybe inflamed Crohn's intestines just uniquely and selectively allow yeast through? If you cut out the Crohn's, can you stop the yeast reaction? Crohn's gets so bad that most patients have to eventually go under the knife and get sections of their intestines removed. So when the inflamed segments are removed, does the yeast reaction go away? No. No change post-op. So a change in Crohn's activity does not lead to a change in the yeast reaction, but we still have to prove that the yeast reaction comes first. Thankfully, the Israeli military systematically draws blood from their recruits, follows their health for years, so you can go back and check the blood of newly diagnosed Crohn's victims. And indeed, those who went on to have Crohn's were years earlier disproportionately reacting to yeast. So it's not like yeast reactions were low until Crohn's hit and then they shot up. Yeast reactivity crept up year after year before the diagnosis. Now look, it's possible that there was some subclinical gut leakiness in the year's preceding diagnosis that led to the yeast reaction, but there doesn't appear to be any association between yeast reactivity and gut leakiness. So do high blood levels of anti-yeast antibodies result from a leakiness of the gut barrier in Crohn's disease? No, that does not appear to be the case. So if Crohn's isn't leading to the yeast reaction, does that mean that the yeast reaction is leading to the Crohn's? Any time you have two things that appear to be associated, in this case reacting to yeast and Crohn's disease, they both can appear tied together because x causes y, or because y causes x. Well, in this case, it appears that y does not cause x, but does that mean that x causes y? Well, there's another option. Maybe there's a third factor that causes both of them independently. Maybe the only reason yeast reactivity and Crohn's disease appear to go together is that there's a third factor causing them both, like, for instance, candida, which I'll cover next.