 DGenies is a free, open-source software package for creating interactive dot-plots from large genome alignments. It allows users to quickly visualize and analyze their data by sorting query sequences against a reference, zooming into specific regions of interest, and downloading multiple images, alignments, and sequence files. This tool is particularly useful for comparing large datasets with minimal effort, as it can handle very large input sizes without any limitations. This article was authored by Florial Cabinets and Christoph Klopp.