 The pandemic has highlighted the need for improved health systems in Africa. To ensure effective response and preparedness for future public health emergencies, the World Health Organization's Regional Office for Africa has developed a transition framework which includes maintaining and consolidating existing response capacities, utilizing digital technology and research innovations, and focusing on primary healthcare and integration of response into routine care. This framework is designed to ensure equitable access to essential services, full engagement and leadership of all stakeholders, and coherent programs aligned with international instruments. This article was authored by Theano Bald, Freddie Muto Cabanza, Joseph Okibuna, and others.