 The Centre for Clinical and Translational Science, CCTS, at the University of Illinois at Chicago has developed a set of core competencies for investigators who are interested in engaging communities in their research. These competencies include understanding the importance of community engagement, recognizing the value of community partnerships, identifying potential stakeholders, building trusting relationships, and creating meaningful collaborations. Additionally, investigators must have knowledge of ethics and regulations related to community-engaged research, as well as the ability to effectively communicate with diverse populations. This article was authored by Alicia K. Matthews, Emporo Castillo, Emily Anderson, and others.