 This systematic review found that the minimal important change, MIC, difference, mid, and minimum detectable change, MDC, estimates were reported for various outcome tools in people with knee osteoarthritis, OA, after non-surgical interventions. The results of this review clarified the current understanding of MIC, mid, and MDC in the knee OA population. However, some estimates suggested considerable heterogeneity and required careful interpretation. This article was authored by Jenny M. Scarville, Angela M. Farron, M. Danica C. Silva, and others.