 1. Human mesenchymal stem cells, MSCs, communicate with other cells in the body and respond to signals of cellular damage by migrating to areas of injury. 2. The migration of MSCs is facilitated by favourable cellular conditions and the in-vivo environment, which are required for effective homing. 3. Strategies for enhancing both environmental and cellular conditions can improve the homing of MSCs, allowing them to quickly find and migrate to injured tissues where they may exert clinical benefits. 4. This article was authored by Sun Kim Kang, Illinois C-Option, Myeong-Soon K-O, and others.