 The maintenance of neuronal integrity and function requires precise mechanisms controlling organelle and protein quality, which is impaired in Alzheimer's disease, AD. Mytophagy, a mitochondrial quality control system, is critical for neuronal homeostasis, and myeloid cell leukemia 1, MCL1, a member of the pro-survival B-cell lymphoma protein 2, BCL2, family, plays a central role in neurogenesis and neuronal survival during brain development. MCL1 regulates neuronal autophagy, mytophagy, and survival, and dysregulation of MCL1 signaling is involved in the pathogenesis of AD. Members of the pro-survival BCL2 family proteins are promising targets of pharmacological intervention with BH3 memetic drugs, and MCL1, targeting therapy shows promise in AD. This article was authored by Abdo Hossein-Rizyan, Wenyi Wei'i, and Hirayuki Inizuka.